Cerebrovascular Reactivity Methodological Advances and Clinical Applications

This volume provides a comprehensive overview of the methodology, physiology, and contemporary and novel applications of cerebrovascular reactivity (CVR) measurements. The chapters in this book cover topics such as an introduction of the neurophysiology, neuroimaging, and clinical methods for CVR measurement; the use of CVR methods in the study of aging, cerebrovascular dysfunction, dementia, and brain tumors; and recommendations for measurement protocols and future applications in clinical translation. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation.

Thorough and comprehensive, Cerebrovascular Reactivity: Methodological Advances and Clinical Applications is a valuable tool that provides researchers in neuroscience and neurology with the latest resources on the measurement, interpretation, and application of CVR measurement.

Series Preface…
Preface…
Table of Contents…
Contributing Authors…

1. The Physiological Basis of Cerebrovascular Reactivity Measurements
Olivia Sobczyk, James Duffin, Joseph A. Fisher, and David J. Mikulis

2. Experimental Protocols in CVR Mapping
Marat Slessarev

3. Molecular Imaging of Cerebrovascular Reactivity
Audrey P. Fan and Oriol Puig Calvo

4. Measurement of Cerebrovascular Reactivity using Transcranial Doppler
Leodante da Costa and Martin Chapman

5. The Role of Cerebrovascular-Reactivity Mapping in Functional MRI: Calibrated fMRI and Resting-State fMRI
J. Jean Chen and Claudine J. Gauthier

6. Hemodynamic Evaluation of Paradoxical Blood Oxygenation-Level Dependent Cerebrovascular Reactivity with Transcranial Doppler and MR-Perfusion in Patients with Symptomatic Cerebrovascular Steno-Occlusive Disease
Christiaan Hendrik Bas van Niftrik, Martina Sebök, Giovanni Muscas, Aimée Hiller, Matthias Halter, Susanne Wegener, Luca Regli, and Jorn Fierstra

7. Cerebrovascular Reactivity (CVR) in Aging, Cognitive Impairment, and Dementia
Hanzhang Lu, Binu P. Thomas, and Peiying Liu

8. Magnetic Resonance Imaging Methods for Assessment of Hemodynamic Reserve in Chronic Steno-Occlusive Cerebrovascular Disease
Keith R. Thulborn, Laura Stone McGuire, Fady T. Charbel, and Sepideh Amin-Hanjani

9. Breath-Hold Cerebrovascular Reactivity Mapping for Neurovascular Uncoupling Assessment in Primary Gliomas
Domenico Zacà, Shruti Agarwal, and Jay J. Pillai

10. Clinical Translation of Cerebrovascular Reactivity Mapping
Manus J. Donahue

11. Recent Advances and Future Directions: Clinical Applications of Intraoperative BOLD-MRI CVR
Giovanni Muscas, Christiaan Hendrik Bas van Niftrik, Martina Sebök, Alessandro Della Puppa, Luca Regli, and Jorn Fierstra

Subject Index List...