Cerebral Microbleeds Pathophysiology to Clinical Practice

Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.

Preface; Foreword Vladimir Hachinski; A short note on terminology; Part I. Historical Aspects, Detection and Interpretation: 1. Historical overview: microaneurysms, cerebral microbleeds and intracerebral hemorrhage Varinder Singh Alg and David J. Werring; 2. Detection of microbleeds – physical principles, technical aspects and new developments Maarten J. Versluis, Andrew G. Webb and Mark A. van Buchem; 3. Susceptibility-weighted imaging E. Mark Haacke, Alexander S. Boikov, Samuel Barnes, Jaladhar Neelavalli and M. Ayaz Khan; 4. Defining and mapping cerebral microbleeds Simone M. Gregoire and David J. Werring; 5. Microbleed mimics Neshika Samarasekera, Gillian Potter and Rustam Al-Shahi Salman; Part II. Mechanisms Underlying Microbleeds: 6. Histopathology of cerebral microbleeds Sebastian Brandner; 7. Risk factors for cerebral microbleeds Lenore J. Launer; 8. Relationship of cerebral microbleeds to other imaging findings Eric E. Smith, David J. Werring and Cheryl R. McCreary; Part III. Microbleeds in Relation to Specific Populations, Diseases and Neurological Symptoms: 9. Microbleeds in healthy populations Bo Norrving; 10. Microbleeds in relation to cerebrovascular disease Seung-Hoon Lee and Jae-Kyu Roh; 11. Microbleeds in relation to hypertensive arteriopathy Eric E. Smith and Roland N. Auer; 12. Microbleeds in relation to cerebral amyloid angiopathy M. Ayaz Khan, Anand Viswanathan and Steven M. Greenberg; 13. Cerebral microbleeds and Alzheimer's disease Charlotte Cordonnier and Wiesje M. van der Flier; 14. Cerebral microbleeds in relation to brain trauma Rainer Scheid; 15. Cerebral microbleeds in CADASIL Anand Viswanathan, Hugues Chabriat and Martin Dichgans; 16. Miscellaneous conditions associated with cerebral microbleeds David J. Werring and Hans Rolf Jäger; 17. Cerebral microbleeds and cognitive impairment David J. Werring and Mike O'Sullivan; 18. Other clinical manifestations of cerebral microbleeds Simone M. Gregoire and David J. Werring; 19. Cerebral microbleeds and antithrombotic treatment Yannie O. Y. Soo and Lawrence K. S. Wong; 20. Cerebral microbleeds and thrombolysis Chelsea S. Kidwell; Index.

Microbleeds have emerged as a critical imaging marker of small vessel disease, responsible for about one in three symptomatic strokes. This text summarizes our current knowledge, bringing together leading research, and will be of interest to clinical researchers and physicians in the fields of stroke and cognitive impairment.

David J. Werring is Clinical Senior Lecturer and Consultant Neurologist at the UCL Institute for Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.