Cellular Drug Delivery Principles and Practice

An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.

Introduction to Cellular Drug Delivery: Present Realities and Future Prospects Kinam Park Part I. Fundamentals of Cell Biology and Cellular Drug Delivery Cellular Structure, Function, and Membrane Transport Emily Ware, D. Robert Lu, and Svein Øie Cellular Growth, Development, and Defensive Response Yan Huang, Guangliang Pan, Svein Øie, and D. Robert Lu Part II. Principles of Cellular Drug Delivery Augmentation of Cell-Mediated Immunity to Virus Erica L. Woodahl and Rodney J. Y. Ho Development of Nonviral DNA Delivery Systems Hans E. J. Hofland, Frank L. Sorgi, and Edward G. Spack Nucleic Acid Cellular Delivery Wu Xiao, Chun Zhang, Preeti Yadava, and Jeffrey Hughes TAT and TAT-Like Peptides for Protein Transduction and Intracellular Drug Delivery Min Jae Lee, Dexi Liu, Guisheng Zhang, and Xiang Gao Carrier-Mediated Mechanisms for Cellular Drug Transport Antara Banerjee, Jeffrey S. Johnston, and Peter W. Swaan ABC Transporter Proteins and Cellular Drug Resistance: P-Glycoprotein and Analogous Transporters William W. Johnson Human Intestinal Cellular Characteristics and Drug Permeability James E. Polli, Anand Balakrishnan, and Paul R. Seo Targeted Drug Delivery to Tumor Cells Using Colloidal Carriers Sushma Kommareddy and Mansoor Amiji Biological Protein Nanostructures and Targeted Drug Delivery Guangliang Pan, Svein Øie, and D. Robert Lu Part III. Practice and Technology of Cellular Drug Delivery Formulation Considerations for DNA-Based Therapeutics Thomas J. Anchordoquy, Taylor K. Armstrong, Marion d.C. Molina, S. Dean Allison, Ye Zhang, Mayank M. Patel, Yvonne K. Lentz, and Gary S. Koe Cationic Microparticles and Emulsions As Effective Delivery Systems for Immune Stimulatory CpG DNA Derek T. O'Hagan, Manmohan Singh, andJeffrey B. Ulmer Transdermal Delivery of Antisense Oligonucleotides WeiQi Lin, Michel Cormier, and Peter E. Daddona Fc Receptor Targeting With Recombinant Immunoglobulins and Immunoglobulin Formulations Adrian Bot and Dan Smith Antibody-Mediated Drug Delivery in Cancer Therapy Zhenping Zhu and Daniel J. Hicklin Automated Property Profiling for Cellular Drug Delivery Edward H. Kerns and Li Di Index