Carbohydrate-Modifying Biocatalysts

This book provides an actual overview of structure, function, and application of carbohydrate-modifying biocatalysts. Unlike amino acids and nucleic acids, carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure and a lack of suited experimental methods for structure determination. Meanwhile, the situation changed with increasing knowledge about carbohydrates, glycoconjugates, and carbohydrate-modifying enzymes together with the key roles they play in biological processes such as recognition, signal transduction, and immune responses. An outcome of research activities in glycoscience, which, at the same time, is of great general interest, is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases.

Basics in Carbohydrate Chemistry, H. HühnerfussGlycoconjugates: An Overview, P. GrunwaldOligosaccharides and Glycoconjugates in Recognition Processes, T. K. LindhorstGlycoside Hydrolases, M. KitaokaDisaccharide Phosphorylases: Mechanistic Diversity and Application in Glycosciences, C. Luley-Goedl and B. NidetzkyEnzymatic and Chemo-Enzymatic Synthesis of Nucleotide Sugars: Novel Enzymes, Novel Substrates, Novel Products, and Novel Routs, L. Engels and L. EllingIteratively Acting Glycosyltransferases, M. Luzhetska and A. BechtholdBacterial Glycosyltransferases Involved in Molecular Mimicry of Mammalian Glycans, W. WakarchukSulfotransferases and Sulfatases: Sulfate Modification of Carbohydrates, Eli Chapman and Sarah R. HansonGlycosylation in Health and Disease, P. GrunwaldSialic Acid Derivatives, Analogs and Mimetics as Biological Probes and Inhibitors of Sialic Acid Recognizing Proteins, J. Tiralongo and T. HaselhorstEnzymes of the Carbohydrate Metabolism and Catabolism for Chemoenzymatic Syntheses of Complex Oligosaccharides, J. Thimm and J. ThiemFrom Gene to Product — Tailor-Made Oligosaccharides and Polysaccharides by Enzyme and Substrate Engineering, J. SeibelSynthesis and Modification of Carbohydrates via Metabolic Pathway Engineering in Microorganisms, X.-W. Liu, L. Li, H.-T. Gao, L.-J. Dang, and P. G. WangMetabolic Pathway Engineering for Hyaluronic Acid Production, E. Marcellin, Wendy Y. Chen, and L. K. NielsenMicrobial Rhamnolipids, M. M. Müller, B. Hörmann, C. Syldatk, and R. HausmannChitin-Converting Enzymes, K. Moß, S. Zibek, T. Hirth, and S. RuppLinear and Cyclic Oligosaccharides, H. TaniguchiFungal Degradation of Plant Oligo- and Polysaccharides, R. P. de Vries, M. Nadal, J. van der Brink, D. A. Vivas-Duarte, and H. StålbrandBacterial Strategies for Plant Cell Wall Degradation and Their Genomic Information, Y. Tamaru and R. H. DoiDesign of Efficient Multi-Enzymatic Reactions for Cellulosic Biomass Processing, Anne S. Meyer