Cancer Genetics and Genomics for Personalized Medicine

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

Personalized Medicine for Cancer: Introduction and Overview of the Book Il-Jin Kim and David Jablons Personalized Medicine in Lung CancerDaniela Morales-Espinosa, Silvia García-Román, and Rafael RosellGenome-Based Personalized Medicine in Liver CancerJae-Jun Shim and Ju-Seog LeeApplications of Circulating DNA Analysis in Personalized Medicine Dana W. Y. Tsui and Muhammed MurtazaCirculating Tumor Cells and Personalized MedicineJin Sun Lee, Mark Jesus M. Magbanua, Marc R. Jabon, and John W. ParkMouse Models in Personalized Cancer Medicine M. E. Beaulieu, T. Jauset, D. Mass?-Vallés, L. Soucek, and J. R. WhitfieldTumor Microenvironment, Therapeutic Resistance, and Personalized MedicineYu SunPersonalized Immune Therapy Joost Hegmans, Lysanne Lievense, and Joachim AertsHyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Malignancies G. E. Bates, P. Kim, C. M. DeRosa, L. Petrukhin, Y. Bressler, and R. N. TaubPersonalized Medicine in Hereditary Cancer Syndromes Rishi Agarwal and Vivek SubbiahPathology in the Era of Personalized Medicine Hye Seung LeeMicroRNAs in Human Cancers Tae Jin Lee and Carlo M. CrocePharmacogenomics of Tamoxifen Hitoshi Zembutsu

Il-Jin Kim is principal investigator and director of Applied Genomics in the UCSF Thoracic Oncology Program. His work focuses on the identification of novel therapeutic targets and diagnostic markers for various types of human cancers. Dr. Kim investigates human cancers using state-of-the-art technologies, including next-generation sequencing (NGS) and system genetic tools that he developed with his team. He has developed several innovative microarrays and pioneered new methods of high-throughput mutation screening, for which he holds numerous patents. He has published more than 70 papers, including in Science and Nature Communications. He has also received three awards from the American Association for Cancer Research for developing innovative genetic and diagnostic assays.