Bioreactors for Tissue Engineering Principles, Design and Operation

For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed.

Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth.

This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

1 Bioractor systems for tissue engineering: A four dimensional challenge.- 2 Microreactor optimization for functional tissue engineering.- 3 Taylor-vortex bioreactors for enhanced mass transport.- 4 Packed bed bioreactors.- 5 Design and operation of a radial flow bioreactor for reconstruction of cultured tissues.- 6 Cartilage growth in magnetic resonance microscopy-compatible hollow fiber bioreactors.- 7 Mechanical conditioning of cell-seeded constructs for soft tissue repair – Are optimisation strategies possible?- 8 Mechanical bioreactors for bone tissue engineering.- 9 A dynamic straining bioreactor for collagen-based tissue engineering.- 10 Bioreactors for ligament engineering.- 11 Biomechanical considerations for tissue engineered heart valve bioreactors.- 12 Design of vascular graft bioreactors.- 13 Perfusion bioreactors for cardiovascular tissue engineering.-14 Haematopoietic culture systems.- 15 Monitoring the performance of tissue engineering bioreactors using magnetic resonance imaging and spectroscopy.- 16 Cryopreservation of hepatocytes for bioartificial liver devices.