Antipsychotics and their Side Effects

With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chapter provides background information about an adverse effect, reviews the evidence linking the effect to various antipsychotics, and provides specific detection and monitoring recommendations. The second section provides unique monitoring guides for each antipsychotic. The third section provides the clinician with a program to monitor patients over the long-term. By supporting rational treatment decisions and systematic adverse effect monitoring, Antipsychotics and their Side Effects provides the clinician with the necessary information and tools for optimizing the safe and effective long-term use of antipsychotic drugs.

Foreword; Preface; Purpose, development, and limitations of Antipsychotics and their Side Effects; Guide to using Antipsychotics and their Side Effects; About the authors; About the cover; Part I. Antipsychotic Side Effects and Monitoring Implications: 1. Introduction; 2. Agranulocytosis and other blood dyscrasias; 3. Anticholinergic effects; 4. Diabetes; 5. Dyslipidemia; 6. Extrapyramidal symptoms; 7. Hepatic effects; 8. Neuroleptic malignant syndrome; 9. Obesity and weight gain; 10. Ocular effects; 11. Prolactin effects; 12. QT prolongation, arrhythmias, and sudden cardiac death; 13. Sedation and sleep disturbances; 14. Seizures; 15. Sexual dysfunction; 16. Sialorrhea; 17. Skin effects and hypersensitivity reactions; 18. Tardive dyskinesia; 19. Urinary incontinence; 20. Venous thromboembolism; 21. Vital signs; Part II. Summary Monitoring Recommendations for Individual Antipsychotics: 22. Aripiprazole; 23. Chlorpromazine; 24. Clozapine; 25. Flupenthixol; 26. Fluphenazine; 27. Haloperidol; 28. Loxapine; 29. Methotrimeprazine; 30. Molindone; 31. Olanzapine; 32. Paliperidone; 33. Pericyazine; 34. Perphenazine; 35. Pimozide; 36. Pipotiazine palmitate; 37. Quetiapine; 38. Risperidone; 39. Thioridazine; 40. Thiothixene; 41. Trifluoperazine; 42. Ziprasidone; 43. Zuclopenthixol; Part III. General Monitoring Form for Patients Taking Antipsychotics; Index.

Antipsychotics are being used at unprecedented rates in primary care and in specialized mental health settings. This book comprehensively reviews the adverse effects of all commonly used older and newer antipsychotics and provides clinician-friendly monitoring resources and recommendations. Essential reading for psychiatrists, general practitioners, pharmacists and nurses.

David M. Gardner is Associate Professor, Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Michael D. Teehan is Associate Professor, Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.