Antibodies in Viral Infection

Antibodies are central to vaccines and it is becoming increasingly apparent that understanding how antibodies combat viruses could be crucial in a new era of vaccine development. This book describes the state of the art in explaining the anti-viral activity of antibodies at the molecular level, with chapters from many of the leaders in the field.

List of Contents.- Antibody Interactions with Rhinovirus: Lessons for Mechanisms of Neutralizationand the Role of Immunity in Viral Evolution.- Structural Studies on Antibody Interacting with Viruses.- Shape and Electrostatic Complementarity at Viral Antigen-Antibody Complexes.- Structural Studies on Viral Escape from Antibody Neutralization.- Affinity, Complementarity, Cooperativity, and Specificity in Antibody Recognition.- Mechanisms of Virus Neutralization by Antibody.- A Model for Neutralization of Viruses Based on Antibody Coating of the Virion Surface.- Antibody-Mediated Enhancement of Viral Disease.- The Role of the Antibody Response in Influenza Virus Infection.- Role of Antibodies in Controlling Alphavirus Infection of Neurons.- Role of Mucosal Antibodies in Viral Infections.- The Role of the Complement System in Virus Infections.- Intrabodies as Antiviral Agents.- T-Bodies as Antiviral Agents.