Advances in Isotope Methods for the Analysis of Trace Elements in Man

There is increasing evidence that even minute amounts of trace elements can have profound effects on the human body. Advances in Isotope Methods for the Analysis of Trace Elements in Man describes new methods that are being developed to understand normal and abnormal trace element nutrition and metabolism. This book includes a wealth of practical advice, encompassing all aspects of isotope methodology, such as the latest developments of analysis techniques for both stable and radioactive isotopes, issues in study design, current cost of isotopes, and analysis. It provides both a historical review of what has been done in the past and details of current techniques and applications. > This state-of-the-art collection from leading experts in the field from Europe and the United States makes a strong case for the practice and advancement of this critical health care tool.

ADVANCES IN STABLE ISOTOPE METHODOLOGYHistoryUsing Stable Isotopes to Study Trace Element MetabolismStable Isotope Dosage, Preparation, and AdministrationConducting Stable Isotope Tracer Studies ADVANCES IN RADIOISOTOPE METHODOLOGYRadioisotopesWhole-Body Counting TechniquesBody Imaging TechniquesIndirect Measurements of Absorption or MetabolismConcluding RemarksTRACER TO TRACEE RATIO FOR COMPARTMENTAL MODELING OF STABLE ISOTOPE DATAIntroductionSingle Pool Tracer Kinetics and MeasurementTracer to Tracee Ratio from Mass Spectrometry MeasurementsMulti Pool Tracer Kinetics and MeasurementThe Multiple Tracer CaseA Test of the Endogenous Constant Steady State AssumptionSoftware Tool: TTRMConclusionsMETHODS FOR ANALYSIS OF TRACE ELEMENT ABSORPTIONIntroductionIronCopperZincSeleniumKINETIC STUDIES OF WHOLE BODY TRACE ELEMENT METABOLISMIntroductionGeneral Considerations in Study DesignCompartmental ModelingSpecific Examples of Isotope Turnover StudiesConcluding RemarksSTABLE ISOTOPE METHODS FOR THE INVESTIGATION OF IRON METABOLISM IN MANIntroductionErythrocyte Incorporation and Iron AbsorptionZincZinc and CopperSeleniumChromiumConclusionsUSE OF ISOTOPES IN THE ASSESSMENT OF ZINC STATUSIntroductionIsotopic TechniquesConclusionsCOPPER STATUS AND METABOLISM STUDIED WITH ISOTOPIC TRACERSIntroductionBackgroundCopper StatusIsotopic TracersConclusionsUSE OF STABLE ISOTOPES OF SELENIUM TO INVESTIGATE SELENIUM STATUSIntroductionDietary Selenium and Its MetabolismThe Role of Selenium in the BodyAssessment of Selenium Status and Use of Stable IsotopesConclusionsUSE OF ISOTOPES FOR STUDIES WITH MANGANESE, CHROMIUM AND MOLYBDENUMManganeseChromiumMolybdenumSummaryTRACE ELEMENT STUDIES IN INFANTS AND PREGNANT OR LACTATING WOMENIntroductionIronZincZinc and CopperSeleniumChromiumConclusionsSTABLE ISOTOPE STUDIES IN THE ELDERLYIntroductionPracticalities of Working with Elderly SubjectsEthical ConsiderationsExamples of Stable Isotope Studies in the ElderlySelenium Status of the ElderlyConclusionsAPPLICATIONS OF TRACE ELEMENT STUDIES IN DEVELOPING COUNTRIES: PRACTICAL AND TECHNICAL ASPECTSIntroductionApplications of Isotope Studies in Developing CountriesPractical Aspects of Implementing Isotope Studies in Developing CountriesTechnical Aspects of Implementing Isotope Studies in Developing CountriesConclusions