Adenosine Receptors Therapeutic Aspects for Inflammatory and Immune Diseases

An overview of how adenosine and inosine regulate immune responses, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases covers aspects of molecular biology, cell biology, and pharmacology. It addresses the role of adenosine receptors in regulating the function of various cell types involved in immune responses. It features data derived from studies using cutting-edge techniques. It discusses disease states such as autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. With contributions from international experts, the text is ideal for researchers in pharmaceutical companies, academic scientists, and clinicians

After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature. Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reader with a general overview of adenosine receptors, delving into molecular biology, cell biology, and pharmacology. Separate chapters focus on the role of adenosine receptors in regulating the function of the various cell types that are involved in immune responses. Further chapters delineate the role of purinergic signaling in the pathophysiology of a variety of disease states associated with an overzealous or insufficient immune response. These include autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. Much of the methodology and findings documented in this text may well lead to new therapeutic modalities for pathologies such as ischemia and reperfusion, heart disease, wound healing, tumors, pain, and a variety of central nervous system diseases including Parkinson’s, Alzheimer’s, and epilepsy, as well as mood and sleep disorders. This resource provides background and direction for those researchers entering the field of adenosine and inflammatory disease, and provides a comprehensive reference for experienced investigators.

Adenosine Receptor Pharmacology; Karl-Norbert Klotz Medicinal Chemistry of Adenosine A3 Receptors; Kenneth A. Jacobson, Yong Chul Kim, Bhalchandra V. Joshi, Zhan-Guo Gao The role of CD73 in the Generation of Extracellular Adenosine for Adenosine Receptor Signaling; Masahide Takedachi, Sean P. Colgan, Linda F. Thompson Regulation of Monocyte/Macrophage Function by Adenosine Receptors; György Haskó, Csaba Szabó Impaired Lymphocyte Activation in the Presence of Adenosine: Mechanisms and Physiologic Relevance; Jonathan Blay, David W. Hoskin Adenosine and Neutrophil Functions; Marc Pouliot Dendritic Cells Regulated by Nucleotides and Nucleosides; Johannes Norgauer, Marco Idzko, Elisabeth Panther, Giampiero Girolomoni, Mirjana Ziemer Adenosine and Endothelial Cell Function; Igor Feoktistov, Italo Biaggioni Adenosine A2B Receptor in the Intestinal Epithelia; Shanthi V. Sitaraman, Vasantha Kolachala, Pallavi Garg Adenosine, Adenosine Receptors and the Regulation of Glial Cells in Neuronal Damage; Gunnar Schulte, Elisabetta Daré, Katrin Färber, Bertil B Fredholm Adenosine Receptors, Wound Healing and Angiogenesis; Aneesh Sheth, Bruce Cronstein A2A Adenosine Receptors and Ischemia Reperfusion Injury; Courtney M. Lappas, Joel Linden Adenosine Signaling in Chronic Lung Disease; Michael R. Blackburn Role of Adenosine in the Control of Inflammatory Events Associated with Acute and Chronic Neurodegenerative Disorders; Jonathan D. Geiger, Lara Buscemi, Julie A. Fotheringham Anti-Inflammatory And Cytoprotective Effects Of Inosine; Csaba Szabó, Domokos Gerô, György Haskó Adenosine And Infection; Christopher Moore, Edward Martin, Gail Sullivan, Joel Linden, W. Michael Scheld Regulation of Peripheral Inflammation by Spinal Adenosine; Sanna Rosengren, Gary S. Firestein Adenosine, Tumors and Immunity; Pnina Fishman, Sara Bar-Yehuda, Lea Madi Adenosine in Atherosclerosis; Allison B Reiss Regulation of Macrophage-Dependent Angiogenesis by Adenosine and Toll-Like Receptors; Samuel Joseph Leibovich.

Gyorgy Hasko, Bruce N. Cronstein, Csaba Szabo