Life Extension

TRAMA

This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans.Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine.This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

SOMMARIO

PrefaceAlexander M. Vaiserman, Alexey A. Moskalev, Elena G. PasyukovaSECTION I: Genetic Regulation of LongevityCHAPTER 1. Neuronal Genes and Developmental Neuronal Pathways in Drosophila Lifespan ControlElena Pasyukova, Alexander Symonenko, Natalia Roshina, Mikhail Trostnikov, Ekaterina Veselkina, Olga RybinaCHAPTER 2. Gadd45 Proteins in Aging and Longevity of Mammals and DrosophilaAlexey A. Moskalev, Ekaterina N. Plyusnina and Mikhail V. Shaposhnikov CHAPTER 3. Superoxide Dismutase (SOD) Genes and Aging in DrosophilaJohn TowerCHAPTER 4. Effect of Wolbachia Infection on Aging and Longevity-Associated Genes in DrosophilaOleksandr M. Maistrenko, Svitlana V. Serga, Alexander M. Vaiserman and Iryna A. Kozeretska SECTION II: Drosophila Models for Aging-Associated DiseasesCHAPTER 5. Skeletal muscle homeostasis and aging in DrosophilaMelissa J. Puppa and Fabio DemontisCHAPTER 6. Drosophila Models of Cardiac Aging and DiseaseAlyson Sujkowski, Chelsea Richardson and Robert WessellsCHAPTER 7. Parallels between Mammals and Flies in Inflammatory Bowel DiseaseTheodoulakis Christofi and Yiorgos ApidianakisCHAPTER 8. Protein Quality Control in Brain Aging: Lessons from Protein Misfolding Disorders in DrosophilaLorena de Mena, Pedro Fernandez-Funez and Diego E. Rincon-LimasCHAPTER 9. Drosophila Models in Therapeutic Drug Discovery Related to AgingCharles Nichols SECTION III: Life-Extending TreatmentsCHAPTER 10. Life-Extending Effect of Phytochemicals in DrosophilaLee Shin-Hae and Min Kyung-JinCHAPTER 11. Life Extension in Drosophila by Histone Deacetylase InhibitorsAlexander M. Vaiserman and Elena G. PasyukovaCHAPTER 12. An Evolutionary Analysis of Healthspan Extension Using Diet: Have We Come to the End of the Ponce de Leon Trail?Grant A. Rutledge and Michael R. RoseCHAPTER 13. Atmosphere, Metabolism and LongevityKhatchik Muradian CHAPTER 14. Effects of Mild Stresses Applied in Adults on Aging and LongevityÉric Le BourgCHAPTER 15. Strategies for Stage-Specific Extension of LongevityRobert ArkingIndex

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9783319183251
• Collana: Healthy Ageing and Longevity
• Dimensioni: 235 x 155 mm Ø 7342 gr
• Formato: Copertina rigida
• Illustration Notes: VIII, 353 p. 49 illus., 26 illus. in color.
• Pagine Arabe: 353
• Pagine Romane: viii