Hematopoiesis

TRAMA

Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the<BR>biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for<BR>therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of<BR>these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of<BR>hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be<BR>illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells andendothelial cells during development and in the adult. Evidence suggests that<BR>endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with h

SOMMARIO

1 - Nature of Hematopoietic Development as Deducible from Clonal Cultures2 - Stem Cells and Hematolymphoid Development3 - Stem Cell Populations and Purification4 - Subtractive Approach to Cloning Genes that Regulate Hematopoiesis5 - Lineage Commitment and Self-Renewal of Blood Stem Cells6 - Blast Cell Colony Assays7 - Quantitative Studies of Normal and Leukemic Stem Cells: Definition and Regulation8 - Normal and Leukemic Stem Cells Assayed in Immune-Deficient9 - Ex Vivo Expansion of Hematopoietic Stem Cells10 - Hematopoietic Stem Cell Gene Therapy: Progress and Prospects11 - Zebrafish Hematopoietic Development12 - Blood Formation During Xenopus Embryogenesis13 - Embryonic Induction of Mammalian Hematopoiesis and Vasculogenesis14 - Developmental Relationships of Hematopoietic Stem Cells and Endothelial Cells15 - Ventral (Yolk Sac) Hematopoiesis in the Mouse16 - Dorsal Hematopoiesis in Fish and Amphibians17 - Non-Yolk Sac Hematopoietic Stem Cells: The Avian Paradigm18 - Hematopoietic Stem Cell Development in Mammals19 - Changes in Lymphoid Progenitor Populations During Mammalian Development20 - Use of Embyronic Stem Cell In Vitro Differentiation in a Serum-Free Environment for Analysis of Mesoderm Formation and Hematopoietic Development21 - Drosophila Hematopoiesis22 - Regulation of Myelopoiesis as Assessed by Gene Deletion and Gene Transduction23 - Hematopoietic Signal Transduction24 - Jak-STAT Signal Transduction25 - Regulation of Erythropoietin Production: Molecular Mechanisms of Oxygen Homeostasis26 - Involvement of Activins and TGFBs in Hematopoiesis27 - Wnts and Hematopoiesis28 - Notch Signaling During Development29 - VLA/B1 Integrins in Hematopoiesis30 - Chemokines31 - Fetal Growth Factor and Hematopoiesis32 - Transcriptional Control During Erythroid and Megakaryocytic Development33 - Transcription Factors that Induce Commitment of Multipotent Hematopoietic Progenitors: Lessons from the MEP System34 - Regulatory Interactions between Transcription Factors and Their Role in Hematopoietic Lineage Determination35 - Nuclear Receptors in Hematopoietic Development: Cooperation with Growth Factor Receptors in Regulation of Proliferation and Differentiation36 - Ets Transcription Factor Mutations and Hematopoiesis37 - Homeobox Genes and the Regulation of Hematopoiesis38 - Myeloid Transcription Factors and Development39 - Megakaryocyte Signaling40 - Transcription Factors Active in Megakaryocytic Development41 - The Role of Myeloproliferative Leukemia in Megakaryopoiesis42 - Mast Cell and Basophil Development43 - The Role of Osteoblasts in Hematopoietic Stem Cell Biology44 - Role of Ikaros Proteins in Lymphocyte Development and Function45 - Transcriptional Regulation of T Cell Development and Activation46 - Signal Tranduction in Thymic Development47 - Lineage Commitment of CD4 T Helper Lymphocytes48 - B-Cell Development and Maturation49 - Development of the Recombinase System50 - The Phylogenetic Development of the Cells that Express and Mechanisms that Diversify Immunoglobulins and T-cell Antigen Receptors51 - Zebrafish Hematopoietic Mutants52 - Spontaneous and Targeted Mutations in Erythrocyte Membrane Skeleton Genes: Mouse Models of Hereditary Spherocytosis53 - Human Bone Marro Failure Syndromes54 - Globin Switching and Developmental Changes in Erythropoietic Sites and Red Blood Cell Populations of Non-Mammalian Vertebrates55 - Globin Switching56 - Dominant White Spotting and Steel Mutants in Hematopoiesis57 - Genomics and Developmental Biology58 - Acute Leukemia: A Disease of Disordered Cell Fate Determination59 - The Microenvironmental Cell Populations Essential for the Support of Hematopoietic Stem Cells60 - The Mediators Involved in the Control of Hematopoiesis by the Microenvironment61 - Development of Stromal Cells62 - Mouse Genetics for the Analysis of Stem Cell Behavior63 - Receptor Tyrosine Kinases in Endothelial and Hematopoietic Cell Development64 - Vascular Endothelial Growth Factor Receptors in Vascular Development and Hematopoiesis65 - Regulation of Hematopoiesis by Bone Marrow Microvascular Endothelium66 - Vascular Matrix and Disorders67 - Vasculogenesis68 - The Angiopoietins and How They Act Coordinately with Vascular Endothelial Growth Factors During Normal and Pathologic Angiogenesis

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9780195124507
• Dimensioni: 213 x 45.7 x 274 mm Ø 2282 gr
• Formato: Copertina rigida
• Illustration Notes: 24pp colour plates, numerous line figures and black and white photographs
• Pagine Arabe: 56