Glial Cell Development

NOTE EDITORE

This is a new edition in the Cellular and Molecular Neurobiology series. The majority of cells in the nervous system are glial cells. During development, these cells provide growth factors that stimulate the proliferation, migration and survival of neurones and their precursors, and promote and guide axonal growth. In the mature nervous system, glial cells provide insulating myelin sheath around axons and provide metabolic and structural support for neurones. Glial cells also have a major influence on the local response to injury of central nerve tracts and the peripheral nervous system, either promoting, or inhibiting, axonal regrowth and recovery of lost function. This book provides a comprehensive, state-of-the-art overview of research into the development, function and malfunction of glial cells. It offers a compelling insight into how basic research throws light onto diseases and disorders and points the way towards treatments. Teams of internationally renowned experts, all active in research, have contributed chapters.

SOMMARIO

1 - Embryonic and early postnatal development of Schwann cells2 - Oligodendrocyte development3 - Developmental origins of astrocytes4 - Microglia in the developing and mature central nervous system5 - The metabolic functions of glial cells6 - The role of ion channels and transmitter receptors in glial cell development7 - Structure and formation of the node of Ranvier8 - Concepts in myelin sheath evolution9 - Myelin-specific genes and their mutations in the mouse10 - Control of gene expression by oligodendrocytes11 - Transcription factors that control Schwann cell development and myelination12 - Genetic analysis of gliogenesis in Drosophila13 - Astrocytes are dynamic participants in central nervous system development and injury response14 - Glial influences on axonal regeneration15 - Axon-Schwann cell interactions during peripheral nerve degeneration & regeneration16 - The molecular genetics of hereditary demyelinating neuropathies17 - Genetic & cellular mechanisms of Schwann cell tumour formation: neurofibromatosis type 1 and neurofibromatosis type 218 - The neuropathology of Multiple Sclerosis19 - Restoring CNS myelin by glial cell transplantation20 - Stem cells and their gliogenic potential21 - Glial tumours of the CNS

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9780198524786
• Collana: Molecular and Cellular Neurobiology Series
• Dimensioni: 248 x 30.0 x 174 mm Ø 1080 gr
• Formato: Copertina rigida
• Illustration Notes: 8pp colour plates, numerous halftones and line figures
• Pagine Arabe: 488