Computational Methods for Reproductive and Developmental Toxicology

NOTE EDITORE

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

SOMMARIO

INTRODUCTIONIntroductionDonald R. MattisonVisions and Advancements for Meeting the Needs of Safety Assessment of Pharmaceutical and Industrial ChemicalsKaren A. Augustine-RauchREACH and Environmental ChemicalsOlivier Taboureau, Karine Audouze, and Søren BrunakREPRODUCTION AND DEVELOPMENT: BIOLOGICAL PROCESSES AND ENDPOINTSFemale Reproductive PhysiologyMariangela Maluf and Paulo Marcelo PerinMaternal Recognition of PregnancyPaulo Marcelo Perin and Mariangela MalufEarly Embryo Development and Bipotential Gonad FormationPaulo Marcelo Perin and Mariangela MalufAssessing the Reproductive Health of Men with Occupational ExposuresSteven M. Schrader, Susan Reutman, and Katherine L. MarlowREPRODUCTION AND DEVELOPMENT: BIOLOGICAL AND COMPUTATIONAL METHODSAnimal Study Protocols and Alternative Assays for the Assessment of Reproductive and Developmental ToxicityAldert H. PiersmaUS National Library of Medicine Resources for Computational ToxicologyPertti J. HakkinenModeling Endocrine Regulation of the Menstrual Cycle Using Delay Differential EquationsLeona A. Harris and James F. SelgradeMolecular Structural Characteristics That Influence Partitioning of Xenobiotics into Human Breast MilkSnezana Agatonovic-Kustrin and David W. MortonApproaches for Pediatric Developmental Drug-Induced Liver InjuryWilliam F. Salminen and Xi YangAdverse Outcome Pathways for Developmental ToxicityDamiano Portinari and Philip N. Judson

AUTORE

Edited by Donald R. Mattison, National Institutes of Health, Bethesda, Maryland, USA, and Risk Sciences International, Ottawa, Ontario, Canada

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9781439861073
• Collana: QSAR in Environmental and Health Sciences
• Dimensioni: 9.25 x 6.25 in Ø 1.52 lb
• Formato: Copertina rigida
• Illustration Notes: 52 b/w images, 13 tables and 42 lines of equations and 51 equations
• Pagine Arabe: 330
• Pagine Romane: xiv