Biotechnology of Plasma Proteins

NOTE EDITORE

The fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to the development of recombinant therapeutic proteins. Discussing the role of plasma proteins in current biotechnology, Biotechnology of Plasma Proteins describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, mass spectrometry, and updates not published since 1975. Key Topics Protein Composition of Plasma Proteomic methods for plasma protein analysis Plasma protein biomarkers Validation of biomarkers Assays for plasma biomarkers Methods for the Analysis of Protein Products Assay development and validation Electrophoresis Chromatography Immunoassay Mass spectrometry Raman spectroscopy Plasma Fractionation: Historical and Modern Methods Development of Cohn alcohol fractionation Industrial methods Development of chromatographic methods Plasma Protein Products of Therapeutic Value Albumin Intravenous immunoglobulin Coagulation products Growth factors Wound management

SOMMARIO

Blood, Plasma, Cells, and Other Biological FluidsPlasma Fractionation and Plasma Protein ProductsMethods for the Analysis of Plasma and Plasma Protein FractionsAlbuminStructure of AlbuminIn Vitro Chemical Modification of AlbuminAlbumin as a CarrierLigand-Binding by AlbuminPurification and Characterization of HSA for Clinical UseBiological Activity of AlbuminEnzymatic Activity of AlbuminClinical Use of AlbuminAlbumin as Diagnostic/BiomarkerPharmacokinetics of AlbuminAnalytical Methods for Albumin Including Use of Albumin as Standard for Analytical MethodsAlbumin as ExcipientConclusionReferencesPlasma ImmunoglobulinsFactor VIII and von Willebrand Factorvon Willebrand FactorEconomic Issues Impacting the Hemophilia BusinessConclusions and Future DirectionsReferencesPlasma Proteinase InhibitorsAntithrombina1-Antitrypsin (a1-Antiprotease Inhibitor, SERPINA1)Heparin Cofactor II (SERPIND1)a2-MacroglobulinTissue Factor Pathway Inhibitora2-AntiplasminC1-Inhibitor (C1-Esterase Inhibitor)Plasminogen Activator Inhibitor-1Protein C Inhibitor (Plasminogen Activator Inhibitor-3)ReferencesVitamin K-Dependent ProteinsMiscellaneous Plasma ProteinsFibrinogenFibrin SealantAutologous Fibrin SealantFibrinogen and Tissue SolderingThrombin and Fibrin FoamFibrinogen PlasticsThrombinPlasminogen and PlasminButyrylcholinesteraseFibronectinReferences

AUTORE

Roger L. Lundblad

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9781439850268
• Collana: Protein Science
• Dimensioni: 9 x 6 in Ø 1.70 lb
• Formato: Copertina rigida
• Illustration Notes: 20 b/w images and 10 tables
• Pagine Arabe: 460