War In The Body - Wick W David; Yang Otto O | Libro Springer 07/2013 - HOEPLI.it

home libri books ebook dvd e film top ten sconti 0 Carrello

Torna Indietro

wick w david; yang otto o - war in the body

War in the Body The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines


Disponibilità: Normalmente disponibile in 15 giorni
A causa di problematiche nell'approvvigionamento legate alla Brexit sono possibili ritardi nelle consegne.

237,98 €
226,08 €

Questo prodotto usufruisce delle SPEDIZIONI GRATIS
selezionando l'opzione Corriere Veloce in fase di ordine.

Pagabile anche con 18App Bonus Cultura e Carta del Docente

Facebook Twitter Aggiungi commento

Spese Gratis


Lingua: Inglese


Pubblicazione: 07/2013
Edizione: 2013


In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.


The HIV Infection model.- The CTL Model.- Simulating an HIV Infection In Vivo.- The Escape Formula.- Early and Late Escapes.- Understanding Escape.- More Topics about Escape from Immune Control.- HIV's Cloaking Device: The Fascinating Story of Nef.- Retroviral Sex and Escape.- The Ne Business Again and a Proposed Experiment.- Can a T-cell Vaccine Block Escape?.- The STEP Trial and the Future of T-cell Vaccines.- Short Tutorial on Dynamical Models.- Deterministic Modeling: A Cautionary Example.- The Infection Model Defined.- The CTL Model Defined.- On Simulation Techniques.- Derivation of the Escape Formula.- Statistics of the Mutant Lineage in Classical Genetics.- Extinction Probabilities with Extra Poisson Variation.- Computing the Boundaries.- Co-existence or Replacement?.- The Nef-Deletion Threshold Formulas.- Modeling Retroviral Sex.


Dr. Yang is a well known T-Cell and HIV expert at UCLA. Dr. Wick is recently retired. His last position was Senior Scientist in the Infectious Diseases Division of the Fred Hutchison Center, in Seattle, where he worked on immune response to HIV and vaccines.

Altre Informazioni



Condizione: Nuovo
Dimensioni: 235 x 155 mm Ø 6033 gr
Formato: Copertina rigida
Illustration Notes:47 Illustrations, black and white
Pagine Arabe: 298
Pagine Romane: xix

Utilizziamo i cookie di profilazione, anche di terze parti, per migliorare la navigazione, per fornire servizi e proporti pubblicità in linea con le tue preferenze. Se vuoi saperne di più o negare il consenso a tutti o ad alcuni cookie clicca qui. Chiudendo questo banner o proseguendo nella navigazione acconsenti all’uso dei cookie.