Use of Nanoparticles in Neuroscience

This volume discusses techniques to synthesize and functionalize nanoparticles, monitor their delivery and uptake, and identify and evaluate their lethal and non-lethal effects on the metabolic activity of the nervous system. The chapters in this book are divided into 4 sections: photo-stimulation, thermal stimulation, mechanical perturbation, and toxicity and physiological effects. The first 3 sections  focus on nanoparticle interactions with external sources that disturb the neuronal system, while the 4th explores the effects of having nanoparticles in a neuronal system in the absence of external stimuli. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, Use of Nanoparticles in Neuroscience is a valuable resource for graduate students and specialized researchers that want to learn techniques needed to quantify experiments that use nanoparticles in the nervous system.

Neuromethods Series Preface…

Preface…

Table of Contents…

Contributing Authors…

1. Optocapacitance Allows for Photostimulation of Neurons without Requiring Genetic Modification

Joao L. Carvalho-de-Souza, Jeremy S. Treger, David R. Pepperberg, and Francisco Bezanilla

2. Nanoparticle-Assisted Localized Optical Stimulation of Cultured Neurons

Flavie Lavoie-Cardinal, Charleen Salesse, Pierre-Luc Ayotte-Nadeau, and Paul De Koninck

3. Stimulation of Primary Auditory Neurons Mediated by Near-Infrared Excitation of Gold Nanorods

Chiara Paviolo, Karina Needham, William G.A. Brown, Jiawey Yong, and Paul R. Stoddart

4. Nanoparticle Preparation for Magnetothermal Genetic Stimulation in Cell Culture and in the Brain of Live Rodents

Idoia Castellanos-Rubio, Rahul Munshi, Shahnaz Qadri, and Arnd Pralle

5. Genetically Encoded Nanoparticle for Neural Modulation

Sarah A. Stanley

6. Two Applications of Gold Nanostars to Hippocampal Neuronal Cells: Localized Photothermal Ablation and Stimulation of Firing Rate

Fidel Santamaria and Xomalin G. Peralta

7. Regulating Growth Cone Motility and Axon Growth by Manipulating Trageted Superparamagnetic Nanoparticles

Tanchen Ren, Jeffrey L. Goldberg, and Michael B. Steketee

8. Assessment of the Effects of a Wireless Neural Stimulation Mediated by Piezoelectric Nanoparticles

Attilio Marino, Satoshi Arai, Yanyan Hou, Mario Pellegrino, Barbara Mazzolai, Virgilio Mattoli, Madoka Suzuki, and Gianni Ciofani

9. Influence of External Electrical Stimulation on Cellular Uptake of Gold Nanoparticles

Samantha K. Franklin, Brandy Vincent, Sumeyra Tek, and Kelly L. Nash

10. Estimating the Effects of Nanoparticles on Neuronal Field Potentials Based on their Effects on Single Neurons In Vitro

Michael Busse, Narsis Salafzoon, Annette Kraegeloh, David R. Stevens, and Daniel J. Strauss

11. The Application of In Vivo Extracellular Recording technique to Study the Biological Effects of Nanoparticles in Brain

12. Using the Whole Cell Patch Clamp Technique to Study the Effect of Nanoparticles in Hippocampal Neurons

Xiaochen Zhang and Zhuo Yang

13. Comparative Analysis of Neurotoxic Potential of Synthesized, Native and Physiological Nanoparticles

14. A Stoichiometrically-Defined Neural Co-Culture Model to Screen Nanoparticles for Neurological Applications

Stuart I. Jenkins and Divya M. Chari

15. Long-Term Organ Distribution Kinetics of Microwave Hydrothermally Synthesixed ZrO2: Pr Nanoparticles in the Organism of Adult Mouse

Jaroslaw Kaszewski, Paula Kielbik, Anna Slonska-Zielonka, Izabela Serafinska, Jakub Nojszewski, Marek Godlewski, Zdzislaw Gajewski, Michal M. Godlewski

16. Gold Nanoparticles as Nucleation Centres for Amyloid Fibrillation

Yanina Alvarez, Jesica V. Pellegrotti, and Fernando D. Stefani