Tumours of the Larynx Histopathology and Clinical Inferences

Close cooperation between those involved in clinical treatment and pathology is imperative in head and neck surgery, as in all surgical fields. The degree of cooperation depends, on the one hand, on the knowledge that the head and neck surgeon has about the possibilities and limits that confront the pathologist, and on the other hand, on the knowledge that the pathologist has about the special problems of head and neck pathology and their management by the surgeon. Within the last 15 years, the knowledge of larynx growths and their treatment has changed rapidly. Parallel to this increase in knowledge, the technical possibilities in histopathology have also increased. For this reason, the authors of this volume present an up-to-date view of the whole scope of the pathology and clinical treatment of larynx tumours.

1 Development, Anatomy, Spatial Compartments and Regions.- 1.1 Development.- 1.2 Postnatal Changes.- 1.3 Anatomy.- 1.4 Regional and Spatial Division.- 2 Particular Problems of Histological Preparation and Assessment: Advanced Methods.- 2.1 Whole-Organ Serial Sections.- 2.2 Histological Evaluation.- 2.3 Advanced Methods in the Evaluation of Precancerous Lesions and Carcinomas.- 2.4 Advanced Methods in the Determination of Tumour Types.- 3 Benign Neoplasms.- 3.1 Definition, Classification, Frequency, General Therapeutic Aspects.- 3.2 Epithelial Tumours.- 3.3 Tumours of Soft Tissue.- 3.4 Tumours of Cartilaginous and Osseous Tissue.- 3.5 Tumours of the Lymphatic and Haematopoietic System.- 3.6 Miscellaneous Tumours, Malformations.- 4 General Conditions and Risk Factors of Carcinogenesis, Precancerous Lesions.- 4.1 Incidence, Age, Sex Distribution and Risk Factors.- 4.2 Papilloma/Papillomatosis and Viral Infection in Laryngeal Carcinogenesis.- 4.3 Chronic Laryngitis.- 4.4 Epidermoid Metaplasia.- 4.5 Multitopic (Multicentric) Tumour Growth: Field Cancerization.- 4.6 Precancerous Lesions.- 4.7 Carcinoma in Situ, Microinvasive Carcinoma.- 4.8 Evaluation of Histological Finding.- 4.9 Therapy of Dysplasia and Carcinoma In Situ of the Larynx.- 5 Squamous Cell Carcinomas.- 5.1 Origin and Spread of Carcinomas.- 5.2 Metastasis.- 5.3 TNM Classification of Laryngeal, Hypopharyngeal and Caudal Oropharyngeal Carcinoma.- 5.4 Histology of Squanomous Cell Carcinoma.- 6 Management of Laryngeal Cancer and Histopathological Inferences.- 6.1 Diagnosis and Prevention.- 6.2 Surgery.- 6.3 Radiation Therapy.- 6.4 Changes Following Treatment with Cytostatic Agents.- 7 Unusual Malignant Tumours.- 7.1 Special Forms of Squamous Cell Carcinoma.- 7.2 Nonepithelial Malignant Tumours.- 7.3 Radiogenic Tumours.- 8 Pseudotumours of the Larynx.- 8.1 Inflammatory Pseudotumours.- 8.2 Laryngeal Cysts and Laryngoceles.- 8.3 Metabolically Induced Pseudotumours.- 8.4 Endolaryngeal Thyroid Tissue.- References.