Introduction 1. A Story of Hope: How RtI Transformed Our High School 2. Core Elements for Establishing an RtI Framework in High Schools 3. Challenges and Limitations for RtI in High Schools4. A Recommended Pathway for Implementing and Maintaining RtI at the High School Level5. Data-Based Decision-Making Embedded across Systems and Tiers6. Strengthen Tier 1 with Professional Development, PLCs, and Standards-Based Assessment7. The Hybrid Approach: Problem-Solving Model with Standard Treatment Protocol8. The Student Support Center as the Hub of Flexible Intervention Delivery9. Tiered High School Math Interventions10. Tiered High School Literacy Interventions11. Sustainability, Conclusions, and Future of High School RtIAppendix A. Criteria for the Determination of SLDAppendix B. Curriculum-Based Measure (CBM) for MathAppendix C. Summary of Research-Based Math StrategiesGlossary of Terms and AcronymsResourcesReferences