Toxicology for the Health and Pharmaceutical Sciences

There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in thepublic and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotalin addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. Key Features: Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.

Preface About the Editors List of Contributors CHAPTER 1. Introduction to ToxicologyMª Teresa Hernández, Mª del Carmen Berrocal, Domingo Ly-Pen, and Mª Victorina Aguilar CHAPTER 2: ToxicokineticsJesús Molpeceres, María de los Angeles Peña & María del Rosario Aberturas Chapter 3: Metabolism and Biotransformation of XenobioticsHilmi Orhan Chapter 4: Mechanistic Toxicology Pramila Singh, Christian Strupp, Werner Bomann Chapter 5. Genetic toxicology and carcinogenesis Pavel Rossner Jr., Radim J. Sram, Andrea Rossnerova Chapter 6: Reproductive and developmental toxicology François Spézia, Paul C. Barrow and Pramila Singh CHAPTER 7: Juvenile Toxicology Paul C. Barrow, Pramila Singh and François Spézia Chapter 8: In vitro toxicity testingGuillermo Repetto, Consuelo Alvarez Herrera, Raquel Rojas, Ana del Peso, Sara Maisanaba Chapter 9. In Vivo Toxicity TestingCarmen González-Martín, Esther Gramage, María José Polanco, Carmen Rodríguez-Rivera Chapter 10. Toxicological applications of genomic, proteomic and metabolomic technologiesCarmen Pérez-García, Francisco Javier Rupérez, María Haro, Gonzalo Herradón Chapter 11: Toxic Effects of Pharmaceuticals and CosmeticsMaria Angeles Peña, Jesus Molpeceres, María del Rosario Aberturas, Antonio Peña-Fernández Chapter 12: Toxicology of Herbal MedicinesHilmi Orhan, Ege Arzuk, Fuat Karakus, Ali Ergüç Chapter 13: Toxicology of industrial chemicalsAntonio Peña-Fernández, Mark D. Evans, Mª Ángeles Peña Fernández Chapter 14: Food ToxicologyArturo Anadón, Irma Ares, Maria Rosa Martínez-Larrañaga and Maria Aránzazu Martínez CHAPTER 15: NanotoxicologyVictorina Aguilar, Maria del Carmen Berrocal, Domingo Ly-Pen and Teresa Hernández Chapter 16: Human Health Risk AssessmentSophie A Rocks Chapter 17: Toxicological modellingGary Moss, Simon Wilkinson Chapter 18: Human Biomonitoring Antonio Peña-Fernández, María de los Ángeles Peña, Marcus S. Cooke Chapter 19: Introduction to Environmental Toxicology Christian Khalil Chapter 20: Exposomics and environmental monitoringSonia Dagnino, Jessica Laine Chapter 21: Pesticide ToxicologyAuthor E. Gordon CHAPTER 22: Pharmaceuticals and Cosmetics as Emerging Environmental Contaminants Carmen José Mateos Vega and María José González Muñoz Chapter 23: Environmental Recovery and RemediationMaría del Carmen Lobo-Bedmar, María Mar Gil-Díaz Chapter 24: Toxicology and Climate ChangeJohn P. Berry Chapter 25: Chemical Warfare and TerrorismHazem Matar and Robert P Chilcott Chapter 26: Toxicology of Drugs of AbuseMarta Vicente-Rodríguez, Gonzalo Herradón and Carmen Pérez-García Chapter 27. Case Studies in Human Toxicology 1: Human health risk assessments for arsenic and beryllium in urban soilsAntonio Peña-Fernández, María José González-Muñoz, Gevorg Tepanosyan, Mark D. Evans, María del Carmen Lobo-Bedmar Chapter 28. Case Studies in Toxicology 2: Recovering environments affected by chemical incidents: The Chemical Recovery Navigation Tool.Antonio Peña-Fernández, Stacey Wyke, Raquel Duarte-Davidson

Dr. Antonio Peña-Fernández is an Associate Professor in Toxicology and Medical Sciences in the Faculty of Health and Life Sciences at De Montfort University, Leicester, UK. He has a BSc in Chemistry from the University of San Pablo CEU, a MSc in Toxicology from the University of Seville. His PhD in Toxicology is from the University of Alcalá (Spain, 2011), where he also holds a Honorary Professorship since 2019. Dr Peña-Fernández’s main research work focuses in human biomonitoring as a tool for the assessment of internal doses of contaminants, and the study of emerging chemical and biological threats in urban, industrial and rural environments for the characterisation of risks and the development of protocols to protect the human health and decontaminate the impacted environments. Many of his current projects are international collaborations with different universities and research institutions from England, Spain and Sierra Leone. Projects relate to environmental monitoring, exposure assessment, building capabilities, and the development of protocols, training materials and tools for the protection of human health to different emerging chemical and biological contaminants. Dr Peña-Fernández became a European Registered Toxicologist (EUROTOX) in 2013 and is a Senior Fellow of the Higher Education Academy (SFHEA, 2016). Dr. Mark Evans is a Senior Lecturer in Biomedical and Medical Science in the Faculty of Health and Life Sciences at De Montfort University, Leicester, UK. He is a graduate of Brunel University (BSc.) and Louisiana State University (PhD) with an extensive academic and research background in the area of free radical biology and oxidative stress. During his career he has worked in the areas of cigarette smoking-induced lung disease, automimmune disease (rheumatoid arthritis, lupus) and cancer and prior to coming to De Montfort University was a postdoctoral scientist then lecturer at The University of Leicester. His primary interests lie in the area of DNA damage/repair and role in disease pathogenesis. Additionally, he has worked in the area of human biomonitoring, examining excreted markers of nucleic acid oxidation and their biological sources, particularly the role of nudix hydrolases. Dr. Evans also has active research interests in the therapeutic potential of natural products, primarily anti-cancer activity and mechanism. Dr. Evans has significant experience of teaching/teaching administration for undergraduate, postgraduate and research students, as well as design of and academic lead for MSc. programmes. Dr. Marcus S. Cooke is a Professor in the Department of Cell Biology, Microbiology and Molecular Biology at the University of South Florida, Tampa, where he heads the Oxidative Stress Group. Dr. Cooke’s background is in the Environmental Health Sciences, in particular Environmental Toxicology. He studies oxidative stress, and genomic instability: from basic mechanisms to translational application of validated biomarkers to study human health and disease. Specifically, the formation and repair of damage to nuclear/mitochondrial DNA and the nucleotide precursor pools; and the development and application of DNA adductomics i.e., (i) the totality of DNA adducts in cellular DNA, and urine; (ii) the genome-wide mapping of DNA damage. Translating such laboratory findings to the marketplace, is a priority, and actively pursued. This has resulted in three US and one UK patents, license agreements, industry collaborations and a STTR award from NIEHS. As of March 2021, Dr. Cooke has 119 peer-reviewed publications, which have attracted over 7500 citations, and he has an h-index of 40.