home libri books Fumetti ebook dvd top ten sconti 0 Carrello


Torna Indietro

marquez victor e. - the ups and downs in drug design

The Ups and Downs in Drug Design Adventures in Medicinal Chemistry




Disponibilità: Normalmente disponibile in 20 giorni
A causa di problematiche nell'approvvigionamento legate alla Brexit sono possibili ritardi nelle consegne.


PREZZO
130,98 €
NICEPRICE
124,43 €
SCONTO
5%



Questo prodotto usufruisce delle SPEDIZIONI GRATIS
selezionando l'opzione Corriere Veloce in fase di ordine.


Pagabile anche con 18App Bonus Cultura e Carta del Docente


Facebook Twitter Aggiungi commento


Spese Gratis

Dettagli

Genere:Libro
Lingua: Inglese
Editore:

CRC Press

Pubblicazione: 11/2021
Edizione: 1° edizione





Note Editore

The Ups and Downs in Drug Design: Adventures in Medicinal Chemistry highlights the necessity for an integrative approach in medicinal chemistry and chemical biology. As medicinal chemistry is not a monolithic science, it is important to emphasize the other various disciplines that are required for successful drug design. This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery. It is an excellent companion text for graduate and postgraduate students who would like further insight into the parameters of drug design, including the challenges that come with the project. Key Features Illustrates "real-life" examples in medicinal chemistry Integrates the use of physical, chemical, and biological concepts that are important in drug design Highlights the "ups" and "downs" that come with drug discovery Aims to inspire students who may be struggling with the challenges and thought process in drug design Intends to be an excellent companion text for graduate and postgraduate students




Sommario

Acknowledgements About the Author Foreword Introduction  Chapter 1. STRUCTURE-ACTIVITY-RELATIONSHIPS (SAR) Chapter 2. BRAIN ANTI-TUMOR AGENTS. THE STORY OF SPIROMUSTIN  Chapter 3. PRIVILEGED DRUG SCAFFOLDS. THE STORY OF LC-6 AND PYRIDINOLCARBAMATE. Chapter 4. CYTIDINE DEAMINASE PART 1.  THE CONCEPT OF TRANSITION-STATE INHIBITORS AND THE DISCOVERY OF ZEBULARINE. Chapter 5. CYTIDINE DEAMINASE PART 2. LESSONS FROM NATURE’S TRANSITION STATE INHIBITORS. Chapter 6. TIAZOFURIN AND THE HISTORY OF THIAZOLE-4-CARBOXAMIDE ADENIDE DINUCLEOTIDE (TAD). Chapter 7. THE AIDS ERA: NUCLEOSIDE ANTIRETROVIRAL AGENTS. Chapter 8. THE AIDS ERA: SYNTHESES OF FLUORONUCLEOSIDES AND THE CLINICAL DEVELOPMENT OF LODENOSINE. Chapter 9. EXPLORATION OF NOVEL NUCLEOSIDE TEMPLATES IN SEARCH OF ACTIVE ANTI-HIV AND ANTIVIRAL DRUGS. Chapter 10.  3-DEAZANEPLANOCIN A AND CYCLOPENTENYLCYTOSINE.  Chapter 11. EPIGENETICS AND CANCER: 5-AZA-CYTIDINE AND ZEBULARINE.  Chapter 12. ZEBULARINE AS AN EPIGENETIC ANTICANCER AGENT. Chapter 13. 3-DEAZANEPLANOCIN A (DZNep) AS AN EPIGENETIC ANTICANCER AGENT. Chapter 14. BICYCLO[3.1.0]HEXANE NUCLEOSIDES. CHEMISTRY. Chapter 15. BICYCLO[3.1.0]HEXANE NUCLEOSIDES. BIOLOGY (PART ONE). Chapter 16. BICYCLO[3.1.0]HEXANE NUCLEOSIDES. BIOLOGY (PART TWO). MORE ON KINASES/POLYMERASES AND DRUG DEVELOPMENT OF N-MCT. Chapter 17. BICYCLO[3.1.0]HEXANE NUCLEOSIDES. BIOLOGY (PART THREE). INVESTIGATING OF MORE EXOTIC TARGETS. Chapter 18. BICYCLO[3.1.0]HEXANE NUCLEOSIDES. CHEMICAL VARIATIONS ON A COMMON THEME. Chapter 19. DIACYLGLYCEROL LACTONES AND PROTEIN KINASE C (PKC). A PHARMACOPHORE-GUIDED APPROACH. Chapter 20. DIACYLGLYCEROL LACTONES AND PROTEIN KINASE C (PKC). TRANSITION FROM A PHARMACOPHORE GUIDED APPROACH TO A RECEPTOR GUIDED APPROACH. References




Autore

Dr. Victor E. Marquez After one year of postdoctoral studies at the National Cancer Institute (NCI)/National Institutes of Health (NIH), Dr. Marquez returned to Venezuela as Research Director of Cosmos Laboratories. In 1977, he rejoined the NCI as a Visiting Scientist, and from 1999 to 2009 he was Chief of the Laboratory of Medicinal Chemistry. In 2008, Dr. Marquez was named Maryland Chemist of the Year, and in 2010 he was inducted into the Medicinal Chemistry Hall of Fame. Dr. Marquez retired as Scientist Emeritus after 32 years of service.










Altre Informazioni

ISBN:

9781032063638

Condizione: Nuovo
Dimensioni: 10 x 7 in Ø 1.93 lb
Formato: Brossura
Illustration Notes:403 b/w images, 76 color images, 51 tables, 20 halftones, 44 color halftones, 383 line drawings and 32 color line drawings
Pagine Arabe: 452
Pagine Romane: xxii


Dicono di noi