The Toxicology of Fishes

The Toxicology of Fishes is an in-depth, state-of-the-science monograph concerning the interactions of chemical contaminants with freshwater and marine fishes. It includes discussions of critical general principles, such as bioaccumulation, toxicokinetics, biotransformations, mechanisms of toxic action, and adaptations to chemical stress and key target systems of fishes, such as liver, kidney, gills, nervous and immune systems, and reproduction. It also covers methodologies and applications for exposure, assessment, toxicity testing, and ecological studies and includes case studies that illustrate the toxicological impacts of important classes of chemical contaminants in real-world settings.

When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on these organisms has been widely available, until now. Filling this void, The Toxicology of Fishes, written by recognized experts, covers toxic responses ranging from reduced reproduction and/or abnormal development, growth, and differentiation. General Principles — Discusses fundamental topics such as the bioavailability of chemicals present in the aquatic environment to fishes, processes governing chemical distribution within these organisms, how fish metabolize organic chemicals, and fundamental mechanisms of chemical toxicity Key Target Systems and Organismal Effects — Describes key target organ systems for chemical impacts in fish, how chemicals produce cancer in these animals, and how fishes can develop resistance to chemical toxicity Methodologies and Applications — Dovers methods for the assessment of chemical effects on fish such as toxicity tests, biomarkers, simulated ecosystems, and modeling approaches and the use of data from such studies in ecological risk assessments Case Studies — Provides examples of how the principles and approaches presented in earlier units are actually deployed in studies Illustrated by case studies of actual, large-scale field investigations, the book reviews the tools used to assess unwanted effects in laboratory model- and wild fish in detail. With 238 illustrations, 70 tables, and 50 equations, this comprehensive monograph presents detailed information on the boiavailability of chemical pollutants, their distribution, metabolism, and excretion in the host fish and mechanisms and sites of toxic responses.

General Principles Introduction, R.T. Di Giulio and D.E. Hinton Bioavailability of Chemical Contaminants in Aquatic Systems, R.J. Erickson, J.W. Nichols, P.M. Cook, and G.T. Ankley Toxicokinetics in Fishes, K.M. Kleinow, J.W. Nichols, W.L. Hayton, J.M. McKim, and M.G. Barron Biotransformation in Fishes, D. Schlenk, M. Celander, E.P. Gallagher, S. George, M. James, S.W. Kullman, P. van den Hurk, and K. Willett Receptor-Mediated Mechanisms of Toxicity, M.E. Hahn and E.V. Hestermann Reactive Oxygen Species and Oxidative Stress, R.T. Di Giulio and J.N. Meyer Key Target Systems and Organismal Effects Liver Toxicity, D.E. Hinton, H. Segner, D.W.T. Au, S.W. Kullman, and R.C. Hardman The Osmoregulatory System, S.E. Wendelaar Bonga and R.A.C. Lock Toxic Responses of the Fish Nervous System, S.P. Bradbury, R.W. Carlson, T.R. Henry, S. Padilla, and J. Cowden The Endocrine System, P. Thomas The Immune System of Fish: A Target Organ of Toxicity, E. Carlson and J.T. Zelikoff Chemical Carcinogenesis in Fishes, J.M. Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, and G.K. Ostrander Toxicity Resistance, P.A. Van Veld and D.E. Nacci Methodologies and Applications Exposure Assessment and Modeling in the Aquatic Environment, D. Mackay and L. Milford Fish Toxicity Studies, G.M. Rand Biomarkers, D. Schlenk, R. Handy, S. Steinert, M.H. Depledge, and W. Benson Aquatic Ecosystems for Ecotoxicological Research: Considerations in Design Analysis for Fish, T.W. La Point, J.H. Kennedy, J.K. Stanley, and P. Balci Ecological Risk Assessment, D.R. Mount and T.R. Henry Case Studies Mining Impacts on Fish in the Clark Fork River, Montana: A Field Ecotoxicology Case Study, S.N. Luoma, J.N. Moore, A. Farag, T.H. Hillman, D.J. Cain, and M. Hornberger Toxicology of Synthetic Pyrethroid Insecticides in Fish: A Case Study, J.R. Coats Reproductive Impairment of Great Lakes Lake Trout by Dioxin-Like Chemicals, D.E. Tillitt, P.M. Cook, J.P. Giesy, W. Heideman, and R.E. Peterson The Effects of Polycyclic Aromatic Hydrocarbons in Fish from Puget Sound, Washington, L.L. Johnson, M.R. Arkoosh, C.F. Bravo, T.K. Collier, M.M. Krahn, J.P. Meador, M.S. Myers, W.L. Reichert, and J.E. Stein Effects of the Exxon Valdez Oil Spill on Pacific Herring in Prince William Sound, Alaska, G.D. Marty Case Study: Pulp and Paper Mill Impacts, M.G. Dubé, K.R. Munkittrick, and L.M. Hewitt Estrogenic Effects of Treated Sewage Effluent on Fish: Steroids and Surfactants in English Rivers, C.R. Tyler, E.J. Routledge, and R. van Aerle Index