The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals Proceedings of the Symposium The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals held in The Hague, The Netherlands, 17–18 February 2000

In 2000 OpdenKamp Registration & Notification organized a two-day symposium in The Hague, The Netherlands, on `The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals'. Several speakers from Europe and the United States were invited to present the different aspects. A vast range of areas was discussed in relation to toxicological modeling and risk assessment, such as occupational toxicology and biomonitoring, exposure to organic solvents and crop protection products, dose-response relations in carcinogenicity, regulatory toxicology, estimation of dermal penetration, uptake and disposition of organic chemicals in fish, the possibilities of in vitro methods in hazard and risk assessment, and the extrapolation between animal and human species. Based on their presentations, the speakers prepared comprehensive papers for this symposium book, reflecting the state of the art of modeling and toxicological risk assessment at the beginning of the third millennium.

List of Contributors. Preface. 1. The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals; V.J. Feron. 2. Physiologically Based Pharmacokinetic Modeling of the Glycol Ether, 2-Butoxethanol, and Its Application in Human Health Risk Assessments and Exposure Guidelines; R.A. Corley. 3. Application of Pharmacokinetic Modelling to Biological Monitoring; P.O. Droz. 4. Dermal Absorption from Pesticide Residues Data Analysis; M.B. Reddy, A. Bunge. 5. Inter-Species Pharmacokinetic Comparison of Organic Acid Herbicides. Is the Dog A Relevant Species for Evaluation of Human Health Risk? C. Timchalk, R. Nolan, R. Billington, D.L. Eisenbrandt. 6. Modeling the Uptake and Disposition of Hydrophobic Organic Chemicals in Fish Using a Physiologically Based Approach; J.W. Nichols. 7. Chair's Introduction to the Second Symposium Day; P.C. Bragt. 8. Can Biologically Based Models of Carcinogenesis Be Used for Risk Assessement? Potentials and Limitations of Carcinogenesis Models; A. Kopp-Schneider. 9. The Prediction of Systemic Toxicity by Integrating the Results of Biokinetic Models and Biologically Based In Vitro Test Methods; B.J. Blaauboer.