The Evolution From Protein Chemistry To Proteomics - Lundblad Roger L. | Libro Crc Press 10/2005 -

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lundblad roger l. - the evolution from protein chemistry to proteomics

The Evolution from Protein Chemistry to Proteomics Basic Science to Clinical Application

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Lingua: Inglese

CRC Press

Pubblicazione: 10/2005
Edizione: 1° edizione

Note Editore

Largely driven by major improvements in the analytical capability of mass spectrometry, proteomics is being applied to broader areas of experimental biology, ranging from oncology research to plant biology to environmental health. However, while it has already eclipsed solution protein chemistry as a discipline, it is still essentially an extension of classical protein chemistry, owing much of its maturation to prior contributions. Unfortunately, this debt is not always evident in current literature. The Evolution from Protein Chemistry to Proteomics: Basic Science to Clinical Application, in providing a different perspective than other reviews, strengthens the connection between solution protein chemistry and proteomic technology. Towards this end, Roger Lundblad, a long-time leader in protein chemistry and a scientist who has worked in both academics and industry, brings together some seemingly disparate areas into a single volume. Discussing analytical proteomics, expression proteomics, and clinical proteomics (biomarker identification), he provides coverage that is uniquely rich in detail. Lundblad applies this detail to sample preparation for proteomic analysis, including preparation from blood and tissues. He also presents specifics on the prefractionation of samples used to identify specific subproteomes such as phosphoproteomes and glycoproteomes. Comprehensive reviews are provided covering the chemical modification of proteins, including its use for chemical proteomics. Special attention is given to challenges that impede the identification, validation, and development of biomarkers into clinically useful diagnostic analytes. A bestselling author, Lundblad utilizes classical protein chemistry literature in providing an intellectual basis for proteomics that merges current concepts with the existing literature, while providing the technical detail necessary for the effective commercialization of proteomics.


A Brief Discussion of Proteomics – Definitions – Concepts – Illusions An Overview of the Chemical Modification of Proteins The Application of Chemical Modification to Proteomics – Chemical Proteomics Sample Preparation for Proteomic Studies Sample Prefractionation An Overview of Analytical Technologies Used in Proteomic Research Clinical Proteomics Validation Issues in Proteomics and the Transition from Research to Diagnostic Development References


Written by a recognized expert, this brilliant work describes the application of chemical modification of proteins to proteomic research, as well as sample preparation, sample prefractionation, analytical technologies, and validation issues in proteomic research. It merges current proteomics concepts into established solution protein chemistry concepts. The author gives particular emphasis to the process by which a biomarker can be identified, validated, and developed into a diagnostic analyte that is useful in clinical applications. According to Proteomics, Lundblad resurrects "the rigorous chemistry literature of the 1950's and 60's, on which most of our present-day knowledge is based."

Altre Informazioni



Condizione: Nuovo
Dimensioni: 9.25 x 6.125 in Ø 1.30 lb
Formato: Copertina rigida
Illustration Notes:113 b/w images and 21 tables
Pagine Arabe: 312

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