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 - the design of covalent-based inhibitors

The Design of Covalent-Based Inhibitors




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Dettagli

Genere:Libro
Lingua: Inglese
Pubblicazione: 07/2021





Note Editore

Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.



  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Annual Report on Medicinal Chemistry series
  • Updated release includes the latest information on The Design of Covalent-Based Inhibitors




Sommario

Preface Richard Andrew Ward and Neil Grimster 1. The history of covalent inhibitors Renato A. Bauer 2. Kinetic Mechanisms of Covalent Inhibition Claire Louise McWhirter 3. Covalent Drugs in Development for Immune-Mediated Diseases Leonard Sung 4. Chemistry Perspectives of Reversible Covalent Drugs Jianmin Gao 5. Design of Next-Generation Covalent Inhibitors: Targeting Residues Beyond Cysteine Lyn Jones 6. Boron and Covalent Inhibition Andrew Leach 7. Measuring and predicting warhead and residue reactivity Christopher Rowley 8. Computational Support of Structure-based Targeted Covalent Inhibitor Design Robert Abel 9. Novel approaches to covalent inhibition Nir London 10. The future of covalent inhibition Gyorgy M. Keseru





Autore

Richard A. Ward is at AstraZeneca, UK
Neil Grimster is at AstraZeneca, USA










Altre Informazioni

ISBN:

9780128216897

Condizione: Nuovo
Collana: Annual Reports in Medicinal Chemistry
Dimensioni: 229 x 152 mm
Formato: Copertina rigida
Pagine Arabe: 298


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