Targeting Enzymes For Pharmaceutical Development - Labrou Nikolaos E. (Curatore) | Libro Humana 11/2020 -

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Targeting Enzymes for Pharmaceutical Development Methods and Protocols

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Lingua: Inglese


Pubblicazione: 11/2020
Edizione: 1st ed. 2020


1. In Silico Laboratory: Tools for Similarity-Based Drug Discovery

            Samo Lešnik and Janez Konc


2. The In Silico Fischer Lock-and-Key Model: The Combined Use of Molecular Descriptors and Docking Poses for the Repurposing of Old Drugs

            Marco Tutone and Anna Maria Almerico


3. Determination of Half-Maximal Inhibitory Concentration of an Enzyme Inhibitor

            Nikolaos Georgakis, Elisavet Ioannou, Christina Varotsou, Geogios Permetis, Evangelia G. Chronopoulou, and Nikolaos E. Labrou


4. Applications of Differential Scanning Fluorometry and Related Technologies in Characterization of Protein-Ligand Interactions

            Bolormaa Baljinnyam, Michael Ronzetti, Adam Yasgar, and Anton Simeonov


5. High-Throughput Differential Scanning Fluorimetry of GFP-Tagged Proteins

            Alanna E. Sorenson and Patrick M. Schaeffer


6. Enzyme-Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism

            Rohanah Hussain, Charlotte S Hughes, and Giuliano Siligardi


7. Measuring Small Molecule Binding to Escherichia coli AcrB by Surface Plasmon Resonance

            Steven W. Polyak, Rumana Mowla, and Henrietta Venter


8. Systematic Screening of Viral Entry Inhibitors Using Surface Plasmon Resonance

            Penmetcha K.R. Kumar


9. Screening of Beta-Secretase Inhibitors by Capillary Electrophoresis-Mass Spectrometry

            Jan Schejbal, Roman Remínek, and Zdenek Glatz


10. Electrophoretic Mobility Shift Assays with GFP-Tagged Proteins (GFP-EMSA)

            Alanna E. Sorenson and Patrick M. Schaeffer


11. On-Line Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors

            Roman Remínek, Zdenek Glatz, and Wolfgang Thormann


12. Enzymatic Bioautographic Methods

            I. Ayelen Ramallo, Mario O. Salazar, and Ricardo L.E. Furlan


13. High-Throughput Assessment of Metabolism-Induced Toxicity of Compounds on a 384-Pillar Plate

            Soo-Yeon Kang, Kyeong-Nam Yu, Pranav Joshi, and Moo-Yeal Lee


14. Droplet-Based Microfluidics Methods for Detecting Enzyme Inhibitors

            Abraham Ochoa, Frida Trejo, and Luis F. Olguín


15. Ligand Fishing: An Approach for the Discovery Inhibitors from Complex Biological Mixtures

            Evangelia G. Chronopoulou, Christina Varotsou, Nikolaos Georgakis, Georgios Permetis, Elisavet Ioannou, and Nikolaos E. Labrou


16. HMG-CoA Reductase as Target for Drug Development

            Baskaran Gunasekaran and Mohd Yunus Shukor


17. Lipoxygenases as Targets for Drug Development

            Xiao-Yuan Mao


18. Cholinesterase as a Target for Drug Development in Alzheimer’s Disease

            Piyoosh Sharma, Manish Kumar Tripathi, and Sushant Kumar Shrivastava


This volume explores detailed methods and experimental protocols evaluating the effect of a compound or a mixture of compounds on the action of enzymes that are significant targets in pharmaceuticals. Consisting of three sections, the book delves into recent biocomputing and bioinformatics protocols, state-of-the art modern biophysical, electrophoretic, and chromatographic methods and high-throughput screening approaches, as well as detailed protocols and examples of the inhibition analysis and evaluation of selected enzymes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and cutting-edge, Targeting Enzymes for Pharmaceutical Development: Methods and Protocols serves as a vital reference for academics and industry professionals working on expanding our understanding of the wide range of important enzyme targets.

Altre Informazioni



Condizione: Nuovo
Collana: Methods in Molecular Biology
Dimensioni: 254 x 178 mm Ø 581 gr
Formato: Brossura
Illustration Notes:42 Illustrations, black and white
Pagine Arabe: 290
Pagine Romane: xi

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