Systems Biology Application in Synthetic Biology

This book introduces students to methods that will help them understand behaviour in terms of cellular components and their interactions in non-intuitive ways, which calls for an interdisciplinary approach combining mathematical, chemical, computational and biological strategies. Tibor Ganti was one of the early pioneers who proposed a theoretical framework to understand living principles in terms of chemical transformation cycles and their coupling. The twenty-first century then brought with it a novel ‘systems’ paradigm, which shone new light on all previous work and was accompanied by numerous implications for the way we conceive of chemical and biological complexity today. 

This book seeks to equip students to take advantage of any field that investigates living systems. Based on a conceptualisation of science-oriented branches, engineering-oriented branches and biology as astoundingly complex fields, those structures laden with biochemical detail encompass a deeper theory unifying our knowledge of designed systems. 

Readers will be pleasantly surprised at how lucidly the topics are presented. The book offers an indispensable resource for students and professionals working in systems and synthetic biology or any of the various related fields of research.

1. Computational Proteomics (Debasree Sarkar).- 2. Design Principles, Network architecture and their Analysis Strategies as Applied to Biological Systems (Ahmad Abu Turab).- 3. Structureomics in Systems-Based Drug Discovery (Lumbini).- 4. Biosensors for Metabolic Engineering (Qiang Yan).- 5. Sustainable Assessment on Using Bacterial Platform to Produce High Added Value Products from Berries through Metabolic Engineering (Lei Pei).- 6. Hindrances to the Efficient and Stable Expression of Transgenes in Plant Synthetic Biology Approaches (Ana Perez Gonzalez).- 7. The new Massive Data: mirNomics and its Application to Therapeutics (Mohammad Ahmed).- 8. Microscopy Based Analysis of Cells Interacting with Nanostructures (Raimo Hartmann).- 9. Mathematical Chemodescriptors and Biodescriptors: Background and their Applications in Systems Toxicology (Subhash Basak).

Shailza Singh is working as Scientist D at National Centre for Cell Science, Pune. She works in the field of Computational and Systems Biology wherein she is trying to integrate the action of regulatory circuits, cross-talk between pathways and the non-linear kinetics of biochemical processes through mathematical models. The current thrust in her laboratory is to explore the possibility of network-based drug design and how rationalized therapies may benefit from Systems Biology. She is the recipient of RGYI (DBT), DST-Young Scientist and INSA (Bilateral Exchange Programme). She is the reviewer of various international and national grants funded from government organizations.