Study On The Cellular Regulation And Function Of Lysine Malonylation, Glutarylation And Crotonylation - Bao Xiucong | Libro Springer 03/2021 - HOEPLI.it


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Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylation




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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 03/2021
Edizione: 1st ed. 2020





Trama

This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases.





Sommario

Introduction to Protein Posttranslational Modifications (PTMs).- Chemical reporter for Lysine Malonylation.- Identification of Histone Lysine Glutarylation.- Glutarylation at Histone H4 lysine 91 Modulates Chromatin Assembly.- Identification of Sirt3 as an ‘Eraser’ for Histone Lysine Crotonylation Marks using a Chemical Proteomics Approach.







Altre Informazioni

ISBN:

9789811525117

Condizione: Nuovo
Collana: Springer Theses
Dimensioni: 235 x 155 mm Ø 291 gr
Formato: Brossura
Illustration Notes:36 Illustrations, black and white
Pagine Arabe: 163
Pagine Romane: xviii






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