Sleep and its Disorders Translational Medicine

The aim of this book is to provide health care professionals with an overview of the main aspects of recent advances in sleep medicine, with an emphasis on advancing basic science into clinical medicine. It is divided into three main parts. The first part is to cover the basic sleep mechanisms which includes genetics in sleep, and neural and humoral regulation of sleep and wakefulness. The second part focuses on the epidemiology of sleep, and the final part consists of the pathophysiological mechanisms of snoring and sleep apnea and other common sleep disorders as well as the consequences. The content of this book is written by experts and sleep specialists from all over the world and this book aims to optimize the health of individuals by “translating” bench side findings into clinical practice.

Chapter 1. Evolving approaches to identifying genetic risk variants for sleep disorders.- Chapter 2. Neurobiology of sleep-wake control.- Chapter 3. Prostaglandins, adenosine and histaminergic system in the regulation of sleep and wakefulness .- Chapter 4.Sleep and Neuronal Plasticity.- Chapter 5. Epidemiology of Insufficient Sleep.- Chapter 6.Social Factors in Insufficient Sleep.- Chapter 7. Sleep Loss and the Unfolded Protein Response.- Chapter 8. Biological and genetic mechanisms of sleepiness in Obstructive Sleep Apnea and Cardiovascular Disease.- Chapter 9.Diaphragm EMG recording and its application in sleep medicine.- Chapter 10. Chronic Intermittent Hypoxia in Patients with OSA.- Chapter 11.Neural injury in models of intermittent hypoxia.- Chapter 12. Narcolepsy and Orexin/hypocretin.- Chapter 13.Circadian Rhythm Sleep-Wake Disorders: Mechanisms and Treatment.

Dr. Allan Pack is a Professor at the Division of Sleep Medicine/Department of Medicine, Perelman School of Medicine, University of Pennsylvania, USA.