Regenerative Medicine and Plastic Surgery Elements, Research Concepts and Emerging Technologies

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. 

Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. 

Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.

Part I - ELEMENTS OF REGENERATIVE MEDICINE

1. Definitions

2. History of Regenerative Medicine

3. Basic Principles and Current Approach for Soft Tissue Regeneration

4. Sophisticated Biocomposite Scaffolds from Renewable Biomaterials for Bone Tissue Engineering

Part II - RESEARCH CONCEPTS

5. Mechanotransduction in wound healing and scar formation

6. Stromal Cell-Derived Factor1 (SDF-1) Signaling and Tissue Homeostasis

7. Stem Cell Differentiation Directed by Material and Mechanical Cues

8. Bacteriophages: a New (Yet Old) Weapon against Infections

9. Bacteriophages as Biocontrol Agents of Biofilm Infections Associated with Abiotic Prosthetic Devices

10. Extracellular vesicles derived from Mesenchymal Stem/Stromal Cells: Current Approaches to Enhance Their Release and Therapeutic Potential

11. Anti-Biofilm Activity of Viruses, Bacteria, Fungi and Lichens: Mechanisms and Impact on Clinical Practice

Part III - EMERGING TECHNOLOGIES

12. Bionic Reconstruction: The New Frontier

13. Carbohydrates in Regenerative Medicine: From Scaffolds to Cell Fate Modulators

14. Biomimetics: A New Abstraction for Bone Implant Design

16. Erythropoietin: An Innovative Therapeutic Approach in Thermal Trauma

17. Targeting C-Reactive Protein in Inflammatory Disease

18. Stem Cell Therapies for Tissue Regeneration and Wound Healing: Strategies to Enhance Therapeutic Effectiveness

19. Iron Chelators & HIF-1a: A new Frontier for Skin Rejuvenation

Part IV - TRANSLATIONAL ASPECTS

20. How to Overcome the Valley of Death from Basic Science to Clinical Trials

21. Moving Your Results from Bench to Bedside: Protecting Scientific Findings

22. The Regulatory Landscape of Cell- and Tissue-Based Regenerative Medicine: Current  Challenges and Emerging Issues

23. Translational Challenges in Soft Tissue Regeneration

24. Bone Tissue Engineering Challenges in Craniofacial Reconstructive Surgeries

26. Implementing Tissue Engineering and Regenerative Medicine Solutions in Silicone Implants

Part V - REGENERATIVE PLASTIC SURGERY

28. Clinical Treatment of Hypertrophic Scars

29. Tissue Engineering and Regenerative Medicine in Oral and Maxillofacial Surgery: The Most Important Clinical Applications of Mesenchymal Stem Cells

30. Reconstruction of Post-Traumatic Maxillary Ridges Using a Radial Forearm Free Flap and Allogeneic Tissue Engineered Bone Grafts

31. Postoperative Complications of Mandibular Fracture Management

32. Use of Porcine Urinary Bladder Matrix (UBM-ECM) in the Head and Neck Region

33. Advances in Facial Nerve Paralysis: Surgical Innovation, Tissue Engineering, and Emerging Technology

35. Soft Tissue Reconstruction of the Lower Limb

Dr. Dominik Duscher MD, PhD, is the director of the Division of Experimental Plastic Surgery at Technical University of Munich. He holds a doctorate of medicine and a research doctorate focusing on Stem Cell Biology and Regenerative Medicine. After his medical education in Vienna (Medical University of Vienna), London (University College London) and Boston (Harvard Medical School) he graduated from a postdoctoral fellowship in Stem Cell Biology and Regenerative Medicine at Stanford University. For his research he received the Stanford University biomaterial research prize, and scholarships from the American Austrian Foundation and the Austrian Science Fund, among other distinctions. Dr. Duscher holds multiple patents, published more than 100 peer reviewed publications and authored more than 100 conference presentations. Dominik Duscher is the General Secretary of the European Plastic Surgery Research Council. He further acts as the Research Coordinator of the Microsurgical Education Center of the Kepler University Hospital Linz and the Young Forum of the Austrian Society for Surgery of the Hand.