Rediscovering Cancer: From Mechanism to Therapy From Mechanism to Therapy

This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.

Genetic Instability in Cancer

Sayali Mukherjee, PhD, is an Assistant Professor at the Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She completed her PhD from the Chittaranjan National Cancer Institute, Kolkata India, registered under Jadavpur University in Life Sciences. She received a NET-CSIR Research Fellowship. During her PhD she has worked on the toxicological and carcinogenic effects of air pollutants on human health. After completing her PhD, she has worked on stem cell culture as a Research Associate at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India. Presently she is working on immunological and biochemical aspects of oral cancer and oral diseases.

Somali Sanyal, PhD, is an Assistant Professor at Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She received her PhD from the Karolinska Medical University, Stockholm, Sweden. During her PhD she has worked on molecular epidemiology of urinary bladder cancer. After her PhD she worked as a postdoctoral fellow at the Karolinska Medical University, Stockholm, Sweden. Later on she moved to the Central Drug Research Institute, Lucknow, India, as a Research Associate. Her current research focuses on genetic aspects of head and neck, oral, and gall bladder cancer. She has published several research articles in journals of national and international repute.

Sonia Chadha, PhD, is presently working as a faculty member at the Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India. She completed her PhD from the Central Drug Research Institute, Lucknow, India, in biochemistry. During her PhD she has worked on the interaction of rat polymorphonuclear leukocyte derived free radical generation and nitric oxide in normal and in various pathological conditions. She has pursued her PDF from the National Environmental Engineering Research Institute (NEERI), Nagpur, India, where she worked on cytochrome P450. Her research interests include biochemical and molecular aspects of cancer and hypertensive disorders. She has several publications in national and international peer-reviewed journals.