Psychiatric Genetics Methods and Reviews

Psychiatric Genetics provides the reader with a complete view of the methodological problems encountered in psychiatry genetics and proposes solutions to commonly occurring questions. The best European and American specialists have given a thorough review on the advantages and disadvantages of genetic epidemiological methods, the way to choose a genetic marker or a clinical interview and how to ascertain patients, unaffected relatives and controls and what should be the criteria to include a case or a control. New phenotypic methods are described focusing on candidate symptom and endophenotype approaches. Examples coming from cognitive neurosciences, biochemistry, electrophysiology and brain imaging techniques are reviewed. This book will serve as an essential handbook for psychiatrists, psychologists, and geneticists involved in the genetics of psychiatric disorders.

Part I. Introduction Psychiatric Genetics: Overview on Achievements, Problems, Perspectives Wolfgang Maier Part II. Methods in Psychiatric Genetics: Advantages and Limits Analytical Methods Applied to Psychiatric Genetics Elena L. Grigorenko and David L. Pauls Genetic Markers in Psychiatric Genetics Thomas Bourgeron and Bruno Giros Clinical Assessment in Psychiatric Genetics Philip Gorwood Genetic Association Studies: Definition of Cases and Controls Frank Bellivier Part III. New Phenotypic Approaches Searching for Alternative Phenotypes in Psychiatric Genetics Marion Leboyer Intermediate Cognitive Phenotypes Associated with Schizophrenia Michael F. Egan and Terry E. Goldberg Biochemical Endophenotypes in Personality Disorders Antonia S. New and Larry J. Siever Electrophysiological Phenotypes Robert Freedman Brain Imaging as an Approach to Phenotype Characterization for Genetic Studies of Schizophrenia Joseph H. Callicott and Daniel R. Weinberger Part IV. Conclusion Psychiatric Genetics: Future and Prospects Ming T. Tsuang, Levi Taylor, and Stephen V. Faraone Index