Proteomic Applications in Cancer Detection and Discovery

Proteomic Applications in Cancer Detection and Discovery provides an up-to-date account of how proteomics has been applied to cancer research and treatment.  It bridges the knoledge gap that exists between scientists that develop and apply proteomics technologies and oncologists who focus on understanding the biological basis behind cancer manifestation and progression.  Without this knowledge, oncologists struggle with how to effectively use the types of data that can be accumulated in large proteomic efforts. Conversely, labs that develop and use proteomics tools lack the fundamental understanding of the information that oncologists require to further their efforst in developing better ways to diagnose and treat cancers. The book includes chapters on: The need for early-stage detection and tailored therapies; The era of systems biology in cancer research; The manifold facets of proteomics; The role of mass spectrometry in cancer discover; Comparative proteomics; Protein-protein complex investigations; Post-translational modification analysis in disease mechanism studies of cancer; The search for biomarkers in biofluids; Proteomic patterns; The critical role of bioinformatics; The emergence of protein arrays; The role of proteomics in personalized medicine; and Future prospects of proteomics in biomarker discovery.