Protein Kinase-mediated Decisions Between Life and Death

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context.  Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information.

Chapter Title

Corresponding Author

Protein kinase-mediated decision between life and death

Atilla ENGIN

Aging, cellular senescence and protein kinases

Ayse Basak ENGIN

ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival

Imran ALI

Signal transduction in immune cells and protein kinases

Monica NEAGU

Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity

Emanuela CORSINI

Metabolic stress and immunity

Dietmar FUCHS

Two-component signal transduction systems in antibiotic resistance

Evren Doruk ENGIN

Oxidative stress-related endothelial cell death and protein kinases 

Atilla ENGIN

Protein kinase inhibitors in traumatic brain injury and repair

Hari SHARMA

Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection

Gregory OXENKRUG

Glucolipotoxicity-related beta cell death and protein kinases

Atilla ENGIN

Amyloid beta toxicity in Alzheimer’s Disease and neuronal death-associated protein kinases

Ayse Basak ENGIN

Protein kinases and cell death in hematological disorders

Ibrahim C. HAZNEDAROGLU

A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy

Basak CELTIKCI

Bile acid toxicity and protein kinases

Atilla ENGIN

Nanoparticle toxicity: Protein kinases and cell death

Ayse Basak ENGIN

Ayse Basak ENGIN, M.Sc., Ph.D., Ph.D., E.R.T., ATS received her undergraduate degree in Pharmacy and MSc. degree in Toxicology from Hacettepe University. She completed her PhD studies in Toxicology and Immunology at Gazi University. She is currently working at the same University, Faculty of Pharmacy, Department of Toxicology as a full professor. Dr. Engin authored/co-authored several publications, book chapters and edited 4 books. She has been awarded Blair-Curtius-Pfleiderer-Wachter Award for Pteridine Research and Turkish Pharmaceutical Science Academy Young Scientist Award. Her work is mainly focused on pteridines and tryptophan metabolism-neurotoxicology, immunotoxicology and nanosafety-nanomedicine.

Atilla ENGIN M.D., Ph.D. was formerly Professor of General Surgery at Gazi University. He is currently professor emeritus. He earned Ph.D. in Biochemistry from Hacettepe University. His doctoral research led to discovery of the relationship between the cancer growth-rate and tissue glutathione concentrations, and these works have been cited for several times and won the “Science Award in Surgery”. He is a pioneer scientist in experimental surgery. His nationally and internationally funded research projects’ findings, book chapters and edited 7 books have been cited in numerous international publications. While some of these outcomes received national and international awards, some of them were included into scientific databases. His work is mainly focused on oxidative stress, endocrine and metabolic pathways.