Pre-Clinical and Clinical Methods in Brain Trauma Research

This volume explores current viewpoints and knowledge gaps in the field of traumatic brain injury (TBI). The chapters in this book cover topics ranging from development of in vitro and animal TBI models, to diagnostic imaging and disease monitoring in patients. Designing pre-clinical and clinical trials is also discussed. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Practical and thorough, Pre-Clinical and Clinical Methods in Brain Trauma Research is a valuable resource for both scientists and clinical researchers interested in learning about important techniques and their applications in the field of TBI.

Traumatic Brain Injury.- Three-Dimensional In Vitro Brain Tissue Models.- Modeling Traumatic Brain Injury In Vitro.- Drosophila Model to Study Chronic Traumatic Encephalopathy.- Controlled Cortical Impact for Modeling Traumatic Brain Injury in Animals.- Fluid Percussion Model of Traumatic Brain Injury.- Development of a Rodent Model of Closed Head Injury: The Maryland Model.- Rodent Model of Primary Blast-Induced Traumatic Brain Injury: Guidelines to Blast Methodology.- Cognitive and Motor Function Assessments in Rodent Models of Traumatic Brain Injury.- Pre-Procedural Considerations and Post-Procedural Care for Animal Models with Experimental Traumatic Brain Injury.- Laser Capture Microdissection of Single Cells, Cell Populations, and Brain Regions Affected by Traumatic Brain Injury.- Rat Microglia Isolation and Characterization Using Multi-Parametric Panel for Flow Cytometric Analysis.- The Principles of Experimental Design and the Determination of Sample Size When Using Animal Models of Traumatic Brain Injury.-  Advanced Informatics Methods in Acute Brain Injury Research.- Rapid Detection and Monitoring of Brain Injury Using Sensory Evoked Responses.- Advanced Neuroimaging Methods in Traumatic Brain Injury.- Dynamic Contrast Enhanced MRI for the Analysis of Blood-Brain Barrier Leakage in Traumatic Brain Injury.- Assessments for Quantifying Neuromotor Functioning after Repetitive Blast Exposure.- Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury.- The Rapid Templating Process for Large Cranial Defects.- Computer-Assisted Approaches to Identify Functional Gene Networks Involved in Traumatic Brain Injury.- Clinical Trials for Traumatic Brain Injury: Designs and Challenges.