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cowley jr. benjamin d. (curatore); bissler john j. (curatore) - polycystic kidney disease

Polycystic Kidney Disease Translating Mechanisms into Therapy

Name: Polycystic Kidney Disease
Price: 98,78 € EUR
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Author: Cowley Jr. Benjamin D. (Curatore); Bissler John J. (Curatore)
ISBN: 9781493992843

cowley jr. benjamin d. (curatore); bissler john j. (curatore)

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Dettagli

Genere:Libro

Lingua: Inglese

Editore:

Springer

Pubblicazione: 07/2019

Edizione: Softcover reprint of the original 1st ed. 2018

Trama

This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Sommario

PART 1. POLYCYSTIC KIDNEY DISEASE GENES & PROTEINS.- 1. Classical Polycystic Kidney Disease (PKD): Gene Structures and Mutations and Protein Structures and Functions.- 2. Bardet-Biedl Syndrome.- 3. Cystic Kidney Diseases Associated with Increased Cancer Risk: Tuberous Sclerosis Complex, Von Hippel Lindau, and Birt Hogg Dubé.- PART 2. POLYCYCSTIC KIDNEY DISEASE: MECHANISMS OF DISEASE.- 4. Aberrant Cellular Pathways in PKD.- 5. Cilia and Polycystic Kidney Disease.- 6. The Role of Inflammation and Fibrosis in Cystic Kidney Disease.- PART 3. CLINICAL FEATURES.- 7. Imaging-based Diagnosis of Autosomal Dominant Polycystic Kidney Disease.- 8. Renal Structural Involvement in Autosomal Dominant Polycystic Kidney Disease: Cyst Growth and Total Kidney Volume: Lessons from the Consortium for Radiologic Imaging of Polycystic Kidney Disease (CRISP).- 9. Renal Complications: Pain, Infection and Nephrolithiasis.- 10. ADPKD Extrarenal Manifestations: Polycystic Liver Disease.- 11. Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease.- PART 4. CLINICAL TRIALS AND EMERGING THERAPIES.- 12. Role of Renin- Angiotensin- Aldosterone System Inhibition in Autosomal Dominant Polycystic Kidney Disease.- 13. Vasopressin Receptor Antagonism.- 14. End-stage Renal Disease in Patients with Autosomal Dominant Polycystic Kidney Disease.- 15. Polycystic Kidney Disease: Translating Mechanisms into Therapy Management of ADPKD Today.

Autore

John J. Bissler, MD

Federal Express Chair of Excellence, Professor and Chief, Division of Nephrology, Department of Pediatrics, Director of the Tuberous Sclerosis Center of Excellence at Le Bonheur Children’s Hospital, Medical Director of Nephrology, St. Jude Children's Research Hospital, University of Tennessee Health Science Center

University of Tennessee Health Science Center

Children’s Foundation Research Center

Memphis, TN

Benjamin D. Cowley, Jr., M.D., F.A.C.P., F.A.S.N.

Professor of Medicine

Chief, Nephrology & Hypertension

John Gammill Professor in Polycystic Kidney Disease

University of Oklahoma Health Sciences Center

Oklahoma City, OK