Polycystic Kidney Disease

Many inherited diseases and non-herediatry disorders have in common the development of renal cyctic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation.
Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis of polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.

Many inherited diseases and non-hereditary disorders have in common the development of renal cystic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation. Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis R polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.

1. - Principles of molecular biology as applied to the study of disease
2. - In vitro models in the study of renal cystogenesis
3. - Mouse models of polycystic kidney disease
4. - In vivo models in non-murine species
5. - Pathogenesis of polycystic kidney disease: basement membrane and extracellular matric
6. - Pathogenesis of polycystic kidney disease: altered cellular function
7. - Classification of cystic kidneys
8. - Diagnostic imaging of renal cystic diseases
9. - Autosomal recessive polycystic kidney disease: clinical and genetic profiles
10. - Acquired renal cystic disease
11. - Tuberous sclerosis
12. - Von Hippel-Lindau Disease
13. - Definition and natural history of autosomal dominant polycystic kidney disease
14. - Cloning strategies and genetics of type 1 autosomal dominant polycystic kidney disease
16. - Hypertension in polycystic kidney disease
17. - Progression to renal insufficiency
18. - Management of end-stage renal failure and problems of transplantation in autosomal dominant polycystic kidney disease
19. - Chronic pain and its medical and surgical management in renal cystic disease
20. - Miscellaneous renal and systemic complications of autosomal dominant polycystic kidney disease including infection
21. - Polycystic liver disease
22. - Intracranial aneurysms in autosomal dominant polycystic kidney disease
23. - Particular problems in childhood and adolescents in autosomal dominant polycystic kidney disease
24. - Counselling and ethical considerations in autosomal polycystic kidney disease