Gastroesophageal reflux (GER) refers to symptoms and events that result from abnormal regurgitation of gastric contents into the esophagus. GER is a common clinical problem that affects large segments of the general population. The spectrum of problems associated with GER is now known to also involve extra-esophageal sites. Respiratory diseases, in particular bronchial asthma, can be exacerbated by multiple triggers, including GER. The relationship between the occurrence of gastroesophageal disorders and changes in respiratory function has been known for over a century, but the mechanism by which intraesophageal acid regurgitation can produce respiratory symptoms is still debated. The reasons for these concurrent pathological events are also not fully understood. Determining, for instance, whether reflux itself initiates or exacerbates asthma, or whether asthma or its treatment primarily causes GER is a matter of current investigation.
Epidemiology of gastroesophageal reflux.- Pathophysiology of gastroesophageal reflux.- Pathological determinants of gastroesophageal reflux, and the role of esophageal and airway receptors.- The role of protons in the activation of primary sensory neurons.- Clinical signs of gastroesophageal reflux.- Epidemiology of GER in asthma patients.- Gastroesophageal reflux and non-specific hyperactivity of upper aerodigestive tract.- Possible correlations with otorhinolaryngological disorders.- Bronchial asthma.- Gastroesophageal reflux in chronic obstructive pulmonary disease.- Gastroesophageal reflux and interstitial lung disease.- Imaging of gastroesophageal reflux.- The esophageal scintiscan.- Ambulatory esophageal pH monitoring in the diagnosis of gastroesophageal reflux.- Lung function and bronchial hyperactivity.- Fiberoptic bronchoscopy and bronchoalveolar lavage in the management of children with gastroesophageal reflux.- Therapy of gastroesophageal reflux disease; the gastroenterologic appraoch.- The role of respiratory drug in GER.- An ovine model of GERd-induced bronchoconstriction.
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Dimensioni: 235 x 155 mm Ø 400 gr
Illustration Notes:42 Illustrations, black and white
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