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broekgaarden mans (curatore); zhang hong (curatore); korbelik mladen (curatore); hamblin michael r. (curatore); heger michal (curatore) - photodynamic therapy

Photodynamic Therapy Methods and Protocols

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Lingua: Inglese


Pubblicazione: 05/2022
Edizione: 1st ed. 2022


This collection explores state-of-the-art methods and protocols for research on photodynamic therapy (PDT) and its use in a wide range of medical applications, from antiviral to anticancer. Beginning with an extensive section on in vitro and in vivo models, the volume continues with chapters on oxygen-independent photosensitizers, next-generation photosensitization strategies, contemporary insights into the immunomodulatory effects of PDT, antimicrobial effects of PDT, as well as a variety of general biochemical and molecular biological techniques. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that ensures successful results in the lab. 

Thorough and authoritative, Photodynamic Therapy: Methods and Protocols serves as an ideal source of inspiration for both new and established PDT scientists and a guide for designing innovative research programs in this continuously advancing and multidisciplinary field.


Part I: In Vitro and In Vivo Models to Study Photodynamic Therapy


1. Application of Monolayer Cell Cultures for Investigating Basic Mechanisms of Photodynamic Therapy

            Mans Broekgaarden


2. The Negative Impact of Cancer Cell Nitric Oxide on Photodynamic Therapy

            Jonathan M. Fahey and Albert W. Girotti


3. Microtumor Models as a Preclinical Investigational Platform for Photodynamic Therapy

            Mans Broekgaarden and Jean-Luc Coll


4. A Microfluidic Model to Evaluate Photodynamic Therapy Treatment Response in 3D Tumors

            Shubhankar Nath, Michael Pigula, Tayyaba Hasan, and Imran Rizvi


5. Analysis of Treatment Effects on Structurally Complex Microtumor Cultures Using a Comprehensive Image Analysis Procedure

            Anne-Laure Bulin, Mans Broekgaarden, and Tayyaba Hasan


6. High-Throughput Examination of Therapy-Induced Alterations in Redox Metabolism in Spheroid and Microtumor Models

            Mans Broekgaarden, Anne-Laure Bulin, and Tayyaba Hasan


7. Spatiotemporal Tracking of Different Cell Populations in Cancer Organoid Models for Investigations on Photodynamic Therapy

            Anne-Laure Bulin and Tayyaba Hasan


8. Generating Large Numbers of Pancreatic Microtumors on Alginate-Gelatin Hydrogels for Quantitative Imaging of Tumor Growth and Photodynamic Therapy Optimization

            Nazareth Milagros Carigga Gutierrez, Tristan Le Clainche, Jean-Luc Coll, Lucie Sancey, and Mans Broekgaarden


9. The Chicken Embryo Chorioallantoic Membrane as an In Vivo Model for Photodynamic Therapy

            Jaroslava Joniová and Georges Wagnières


10. Subcutaneous Xenograft Models for Studying PDT In Vivo

            Girgis Obaid and Tayyaba Hasan


11. In Vivo Models for Studying Interstitial Photodynamic Therapy of Locally Advanced Cancer

            Gal Shafirstein, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Sarah Chamberlain, Sandra Sexton, Leslie Curtin, and David A. Bellnier


12. Orthotopic Models of Pancreatic Cancer to Study PDT

            Girgis Obaid, Zhiming Mai, and Tayyaba Hasan


13. An Orthotopic Murine Model of Peritoneal Carcinomatosis of Ovarian Origin for Intraoperative PDT

            Thierry Michy, Claire Bernard, Jean Luc Coll, and Véronique Josserand


14. Photodynamic Treatments for Disseminated Cancer Metastases Using Fiber-Optic Technologies

            Eric M. Kercher and Bryan Q. Spring


15. Stereotaxic Implantation of F98 Cells in Fischer Rats: A Syngeneic Model to Investigate Photodynamic Therapy Response in Glioma

            Anne-Laure Bulin, Jean-François Adam, and Hélène Elleaume


Part II: Inorganic Photosenstizers and Light-Activatable Anti-Cancer Prodrugs


16. New Generation of Photosensitizers Based on Inorganic Nanomaterials

            Xiaomin Liu and Hong Zhang


17. Cytotoxicity of Metal-Based Photoactivated Chemotherapy (PACT) Compounds

            Vadde Ramu, Austin B. Auyeung, and Sylvestre Bonnet


Part III: Third and Fourth-Generation Photosensitizers


18. Photosensitized Oxidation of Intracellular Targets: Understanding the Mechanisms to Improve the Efficiency of Photodynamic Therapy

            Thiago Teixeira Tasso and Maurício da Silva Baptista


19. Inhibition of the HIF-1 Survival Pathway as a Strategy to Augment Photodynamic Therapy Efficacy

            Mark J. de Keijzer, Daniel J. de Klerk, Lianne R. de Haan, Robert T. van Kooten, Leonardo P. Franchi, Lionel M. Dias, Tony G. Kleijn, Diederick J. van Doorn, and Michal Heger on behalf of the International Photodynamic Therapy Study Group


20. Strategies for Improving Photodynamic Therapy through Pharmacological Modulation of the Immediate Early Stress Response

            Daniel J. de Klerk, Mark J. de Keijzer, Lionel M. Dias, Jordi Heemskerk, Lianne R. de Haan, Tony G. Kleijn, Leonardo P. Franchi, and Michal Heger on behalf of the International Photodynamic Therapy Study Group


21. Nanobody-Targeted Photodynamic Therapy: Nanobody Production and Purification

            Vida Mashayekhi, Erik Schooten, Paul M.P. van Bergen en Henegouwen, Marta M. Kijanka, and Sabrina Oliveira


22. Conjugation of IRDye Photosensitizers or Fluorophores to Nanobodies

            Vida Mashayekhi and Sabrina Oliveira


23. In Vitro Assessment of Binding Affinity, Selectivity, Uptake, Intracellular Degradation, and Toxicity of Nanobody-Photosensitizer Conjugates

            Irati Beltrán Hernández, Timo W.M. De Groof, Raimond Heukers, and Sabrina Oliveira


24. Assessment of the In Vivo Response to Nanobody-Targeted PDT through Intravital Microscopy

            Henriette S. de Bruijn, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Sabrina Oliveira, and Dominic J. Robinson


25. Orthotopic Breast Cancer Model to Investigate the Therapeutic Efficacy of Nanobody-Targeted Photodynamic Therapy

            Marion M. Deken, Shadhvi S. Bhairosingh, Alexander L. Vahrmeijer, and Sabrina Oliveira


26. Investigation of the Therapeutic Potential of Nanobody-Targeted Photodynamic Therapy in an Orthotopic Head and Neck Cancer Model

            Pieter B.A.A. van Driel, Stijn Keereweer, Clemens W.G.M. Lowik, and Sabrina Oliveira


Part IV: Photodynamic Therapy-Induced Immune Signaling


27. Evaluation of the Antitumor Immune Response Following Photofrin-Based PDT in Combination with the Epigenetic Agent 5-Aza-2’-Deoxycytidine

            Malgorzata Wachowska, Angelika Muchowicz, and Jakub Golab


28. Controlling Immunoregulatory Cell Activity for Effective Photodyna

Altre Informazioni



Condizione: Nuovo
Collana: Methods in Molecular Biology
Dimensioni: 254 x 178 mm Ø 1622 gr
Formato: Copertina rigida
Illustration Notes:XVI, 752 p. 142 illus., 114 illus. in color.
Pagine Arabe: 752
Pagine Romane: xvi

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