Pharmacogenomics in Drug Discovery and Development

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. 

Target Discovery for Drug Development Using Mendelian Randomization.- Human Leukocyte Antigen (HLA) Testing in Pharmacogenomics.- Pharmacogenomics in Targeted Therapy and Supportive Care Therapies for Cancer.- Pharmacogenomics in Cytotoxic Chemotherapy of Cancer.- Management of Side Effects in the Personalized Medicine Era: Chemotherapy-Induced Peripheral Neuropathy.- The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine.- Design of Personalized Neoantigen RNA Vaccines Against Cancer Based on Next Generation Sequencing Data.- COVID-19 Pharmacotherapy: Drug Development, Repurposing of Drugs, and the Role of Pharmacogenomics.- Pharmacogenomics Informs Cardiovascular Pharmacotherapy.- Pharmacogenomic Screening of Patient-Specific hiPSC-Derived Cardiomyocyte Drug Candidates Using High-Throughput Calcium Imaging.- The Yin-Yang Dynamics in Cardiovascular Pharmacogenomics and Personalized Medicine.- GTPgS Assay for Measuring Agonist-Induced Desensitization of Two Human Polymorphic Alpha_2B-Adrenoceptor Variants.- Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development.- Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.- The Pharmacogenetic Impact on the Pharmacokinetics of ADHD Medications.- Pharmacogenetics of Addiction Therapy.- Pharmacogenomics of Opioid Treatment for Pain Management.- The Role of Pharmacogenomics in Postoperative Pain Management.- Pharmacogenetics of Drug Therapies in Rheumatoid Arthritis.- Pharmacogenomics in Children.- Genetic Ancestry Inference for Pharmacogenomics.