Pharmaceutical Biocatalysis Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients

This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.

Future Strategies for Commercial Biocatalysis Robert E. Speight and Karen T. Robins Synthetic Approaches to Inhibitors of Isoprenoid Biosynthesis Pedro Merino et al. Using a Recombinant Metagenomic Lipase for Enantiomeric Separation of Pharmaceutically Important Drug Intermediates Rakesh Kumar, Uttam Chand Banerjee, and Jagdeep Kaur Biotechnological Production of Prenylated Xanthones for Pharmaceutical Use Mariam Gaid et al. Chemoenzymatic Approaches Towards (S)-Duloxetine Danish Shahzad, Muhammad Faisal, and Aamer Saeed Synthesis of Antioxidants via Biocatalysis Salman Zafar Biocatalysts: The Different Classes and Applications for Synthesis of APIs Peter Grunwald Laccase-Mediated Synthesis of Novel Antibiotics and Amino Acid Derivatives Annett Mikolasch Hydrolytic Enzymes for the Synthesis of Pharmaceuticals Sergio González-Granda and Vicente Gotor-Fernández Ene-Reductases in Pharmaceutical Chemistry Katrin Hecht and Rebecca Buller Biocatalyzed Synthesis of Antidiabetic Drugs Andrés R. Alcántara Glucose-Sensitive Drug Delivery Systems Based on Phenylboronic Acid for Diabetes Treatment Li Zhao et al. Synthesis of Important Chiral Building Blocks for Pharmaceuticals Using Lactobacillus and Rhodococcus Alcohol Dehydrogenases Marion Rauter, Simon Krebs, Gotthard Kunze Asymmetric Reduction of C=N Bonds by Imine Reductases and Reductive Aminases Matthias Höhne, Philipp Matzel, and Martin Gand Cipargamin: Biocatalysis in the Discovery and Development of an Antimalarial Drug Thomas Rucha, Elina Siirola, and Radka Snajdrova Halogenases with Potential Applications for the Synthesis of Halogenated Pharmaceuticals Georgette Rebollar-Pérez et al. Conversion of Natural Products from Renewable Resources in Pharmaceuticals by Cytochromes P450 Giovanna Di Nardo and Gianfranco Gilardi Oxyfunctionalization of Pharmaceuticals by Fungal Peroxygenases Jan Kiebist et al. Biocatalytic Synthesis of Chiral 1,2,3,4-Tetrahydroquinolines Yongzheng Chen, Liu Song, and Zhongqiang Wang New Strategies to Discover Non-Ribosomal Peptides as a Source of Antibiotics Molecules Mario Alberto Martínez-Núñez, Zuemy Rodríguez-Escamilla, and Víctor López y López Enzyme Kinetics and Drugs as Enzyme Inhibitors Peter Grunwald

Peter Grunwald