Pathology of Peritoneal Metastases The Unchartered Fields

This book covers some well-known and some unexplored pathological aspects of management of peritoneal metastases and should be read by both surgeons and pathologists involved in the management of peritoneal surface malignancies. The evaluation of cytoreductive surgery specimens is explored for the prognostic information it can provide and recommendations for evaluation of such specimens are provided. The pathways and patterns of peritoneal dissemination and their clinical implications on the extent of surgery performed and other aspects of management are discussed for some common peritoneal tumours. The exploratory studies presented here provide a new perspective on the surgical resection of peritoneal metastases.

Other important aspects of pathological evaluation like pathological response to chemotherapy, diagnosis and classification of rare peritoneal tumors have also been covered in different chapters. Keeping in sync with the progress in molecular oncology, the role of molecular oncology in the current and future management of peritoneal metastases is addressed for different tumors. 

Mechanisms of peritoneal cancer dissemination and their clinical implications.- Data set for reporting peritonectomy specimens.- Patterns of peritoneal dissemination in colorectal cancer.- Patterns of peritoneal dissemination in ovarian cancer.- Peritoneal mesothelioma- disease biology and patterns of peritoneal dissemination.- Patterns of peritoneal recurrence  following cytoreductive surgery.- The pathological spectrum of pseudomyxoma peritonei.- Rare peritoneal tumors- essentials for diagnosis and reporting.- Approach to a patient with peritoneal metastases with unknown primary site.- Biomarkers and the management of peritoneal metastases- A future perspective.

Professor Olivier Glehen is a world renowned expert in peritoneal surface oncology and a member of the executive committee of the peritoneal surface oncology group international (PSOGI). He is the head of the General and Oncologic Surgery Department at Centre Hospitalier Lyon Sud (Hospices Civils de Lyon) and at the Lyon Sud Charles Mérieux Medical Faculty. His centre is one of centres that have pioneered the surgical treatment of peritoneal metastases in the world. He is director of the Peritoneal Carcinomatosis Research Group from the EMR 3738 (Claude Bernard Lyon 1 University).

He has published extensively about peritoneal metastases. He is at the head of RENAPE (French Network on rare peritoneal tumours) and BIG-RENAPE groups (National Clinic-Biological Database on Digestive Peritoneal Carcinomatosis). He is associate editor of European Journal of Surgical Oncology, Journal of Surgical Oncology and Journal of Peritoneum. Professor Glehen is one of the directors of the Inter-University Diploma on Peritoneal Carcinomatosis in France and his centre is a reference centre for the European Society of Peritoneal Surface Oncology (ESPSO) certified fellowship in peritoneal surface oncology. His centre performs more than 200 cytoreductive surgery and HIPEC (Hyperthermic Intraperitoneal Chemotherapy) procedures a year and is also one of the leading centers in the world that is developing PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy). 

Dr Aditi Bhatt is an Indian surgical oncologist specializing in the management of peritoneal surface malignancies with an experience of 10 years in the same. She is one of the founding members of the Society of peritoneal surface oncology, India, the Indian HIPEC registry and serves as the honorary secretary of the Asian Peritoneal Surface Malignancy Group.

She has published several scientific papers on the subject, edited two special issues of the Indian Journal of Surgical Oncology on the same and edited a book on peritoneal surface malignancies.