Pathogenesis, Management and Socio-Economic Impact of COVID-19 Pandemic

This book provides up-to-date insights into the COVID-19 disease, addressing its outbreak, pathogenesis, biology, treatment interventions, and consequences as a global health crisis. Divided into six sections, the book covers a detailed examination of various facets of the disease. Section I delves into the host's genetic and epigenetic mechanisms in response to COVID-19. Section II focuses on disease diagnosis, providing valuable perspectives on kits, nucleic acid testing, immunological assays, imaging-based diagnosis, and variant-specific SARS-COV-2 detection. Section III covers cytokine storm, inflammation, and immunity, including the modulation of signaling pathways leading to immune evasion and persistence. Section IV reveals drug repurposing, exploring antiviral, anti-inflammatory, anti-platelet drugs, and target-based drug discovery. Section V explains the evolution of vaccine development including DNA, RNA, subunit, and viral vaccines. Finally, Section VI explores COVID-19'simpact on associated comorbidities, ranging from cancer and cardiac issues to neurological damages and economic consequences.

The book is relevant for scientists, and researchers working on pathogenesis, development, implementation, host-pathogen interactions, and drug repurposing of COVID-19 disease.

Part 1 COVID-19 Pandemic: Pathogenesis, Inflammation, and Biology.- Ch 1 The COVID-19 Outbreak.- Ch 2 Pathogenesis and Biology of SARS-CoV-2.- Ch 3 COVID-19: Modulation of Host’s Genetic and Epigenetic Machineries.- Ch 4 SARS-CoV-2 Mutants and Variants of Interest.- Part 2 COVID-19: Diagnosis and Development of Diagnostics.- Ch 5 Imaging-Based COVID-19 Diagnosis.- Ch 6 Nucleic Acid Amplification Testing (NAAT) based COVID-19 Kits.- Ch 7 Immunological Assay Based COVID-19 Detection.- Ch 8 Variant-Specific Diagnosis of COVID-19.- Part 3 COVID-19: Immunological Perspectives.- Ch 9 Cytokine Storm, Inflammation, and Immunity in COVID-19.- Ch 10 COVID-19: Modulation of Signaling Pathways.- Ch 11 Immunological Persistence and Risk of SARS-CoV-2 Re-infection: Insights and Implications.- Ch 12 Plasma Therapy in COVID-19.- Part 4 COVID-19 Drug Repurposing: Mode of Action, Clinical Trials, and Future Perspectives.- Ch 13 Repurposing of Anti-viral Agents in COVID-19.- Ch 14 Role of Anti-inflammatory Agents in the Management of COVID-19.- Ch 15 Application of Anti-platelet Drugs and Anti-coagulants in COVID-19.- Ch 16 COVID-19: Target-Based Drug Discovery.- Part 5 COVID-19: Vaccine Development and Vaccination.- Ch 17 COVID-19: Vaccine Classification and their Clinical Status.- Ch 18 SARS-CoV-2: A Comprehensive Insight into DNA, RNA, Subunit, and Viral Vaccines.- Ch 19 COVID-19 Vaccination in Medically Distinct Population.- Part 6 COVID-19 Associated Comorbidities, Economic and Societal Impact.- Ch 20 Neurological damages in COVID-19 patients.- Ch 21  COVID-19 Comorbidities in Cancer.- Ch 22 Interplay of COVID-19 with Tuberculosis and Pneumonia: Challenges and Treatment.- Ch 23 Economic Consequences of the COVID-19 Pandemic.- Ch 24 COVID-19 Pandemic and Its Societal Impact: A Philosophical/Theoretical Perspective in Human Quantum Mechanics.- Ch 25 Unravelling the Global Economic Impact: A Region and Sector-wise Post-COVID Analysis.- Ch 26 Navigating Long COVID: Comorbidities and the Global Societal Impact.

Dr. Mrinal K Ghosh is a chief scientist, In-Charge of CSIR-IICB(TRUE), Salt Lake Campus and head (2019-2025) of the cancer biology and inflammatory disorder division at CSIR- Indian Institute of Chemical Biology (IICB), Kolkata, India; chairman of management council at CSIR-IICB (TRUE) and a professor at the Academy of Scientific and Innovative Research (AcSIR), India. He completed his Ph.D. from the University of Calcutta and postdoctoral research (1997 – 2005) from Cleveland Clinic Foundation, OHIO, USA. Dr. Ghosh’s research interests include signal transduction in cancer focusing on the regulation of various oncogenes and tumor suppressor proteins at transcriptional, and post-translational levels, and developing nanotechnology-based targeted drug delivery systems to target identified molecular vulnerabilities in brain, breast, and colon cancers. He has written several papers in peer-reviewed national and international journals, authored books, delivered numerous lectures, and is a reviewer of various national and international journals. Dr. Ghosh is a lifetime member of the Indian Society of Translational Research (ISTR), the Chemical Biology Society (CBS), the Indian Association of Cancer Research (IACR), the Society of Biological Chemistry (SBC), and the Indian Science Congress Association (ISCA), India.

Dr. Malini Basu is an assistant professor and head at the department of microbiology, Dhruba Chand Halder College, University of Calcutta, Kolkata, India. She completed her Ph.D. from the University of Calcutta and postdoctoral research from Case Western Reserve University, USA in collaboration with Rainbow Babies and Children Hospital, Ohio, USA. Dr. Basu’s research interests include heavy metals, microbial bioremediation and bioindicators, unique virulence, pathogenicity, and host immune response of Helicobacter pylori in gastric cancer. She has written several papers in peer-reviewed national and international journals and some book chapters. Dr. Basu is a lifetime member of the Microbiologists Society India (MBSI), the Association of Microbiologists of India (AMI), and ISNA. She is also the state vice-president of the Microbiologists Society of India.