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dickson d - neurodegeneration – the molecular pathology of dementia and movement disorders 2e

Neurodegeneration – The Molecular Pathology of Dementia and Movement Disorders 2e Molecular Pathology of Dementia and Movement Disorders

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Lingua: Inglese
Pubblicazione: 11/2011
Edizione: 2000 2ª


Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, ?-synuclein and TDP-43) and in the extracellular compartments (e.g. ?-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts

Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis.

This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Note Editore

The basic concept of the book will be to classify and group Dementias and Movement disorders in terms of Molecular Pathology, a strategy that proved to be successful in the first edition in 2003 (sales 2003-2005 = 1017 copies). Since 2003 there have been so many significant advances in the field that a new book is urgently required. Authors will be drawn from the wide field of experts in the International Society of Neuropathology and related disciplines.

Altre Informazioni



Condizione: Nuovo
Collana: International Society of Neuro
Dimensioni: 287 x 38.99 x 215 mm Ø 1946 gr
Formato: Copertina rigida
Pagine Arabe: 496

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