Nanoparticles in the Lung Environmental Exposure and Drug Delivery

Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger (e.g., micrometer) particles, are considered to behave differently when they interact with cells. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery provides a better understanding of how inhaled nanoparticles behave in the human lungs and body. Featuring contributions from renowned subject-matter experts, this authoritative text describes the sequence of events that nanoparticles encounter in the lungs when moving from the air into the bloodstream. This includes deposition, interactions with the alveolar surface and epithelium, translocation across the air–blood tissue barrier, and accumulation in the body. In addition, the book addresses practical considerations for drug delivery to the respiratory tract, drug and gene delivery in the lungs, and bio-nanocapsules. It considers the physicochemical, colloidal, and transport properties of nanoparticles, and presents cutting-edge research on special issues such as dosimetry for in vitro nanotoxicology, nanoparticle deposition in the developing lungs, and the potential for nose-to-brain delivery of drugs. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery offers the most updated and comprehensive knowledge of the risks and benefits associated with nanoparticle inhalation—to protect humans from any harmful effects and to explore the utility of nanoparticles as drug delivery carriers.

Foreword Preface Editors Contributors Introduction; Akira Tsuda and Peter Gehr Section I: Gas Phase Deposition; Akira Tsuda and Frank S. Henry Section II: Airway/Alveolar Surface Interaction with the Lung Surface; Peter Gehr and Akira Tsuda Role of the Biomolecule Corona in Nanoparticle Fate and Behavior; Iseult Lynch Interaction with Alveolar Lining Fluid; Vincent Castranova, Dale W. Porter, and Robert R. Mercer Interaction with Lung Macrophages; Barry Weinberger, Patrick J. Sinko, Jeffrey D. Laskin, and Debra L. Laskin Section III: Crossing Epithelial Cells Interactions with Alveolar Epithelium; Farnoosh Fazlollahi, Yong Ho Kim, Arnold Sipos, Zea Borok, Kwang-Jin Kim, and Edward D. Crandall Mechanistic Aspects of Cellular Uptake; Lennart Treuel, Xiue Jiang, and Gerd Ulrich Nienhaus Cellular Uptake and Intracellular Trafficking; Barbara Rothen-Rutishauser, Dagmar A. Kuhn, Dimitri Vanhecke, Fabian Herzog, Alke Petri-Fink, and Martin J.D. Clift Section IV: Translocation Translocation across the Air–Blood Tissue Barrier; Fabian Blank, Christophe von Garnier, Peter Gehr, and Barbara Rothen-Rutishauser The Pulmonary Lymphatic System; Akira Tsuda Translocation and Accumulation in the Body; Wolfgang G. Kreyling Section V: Drug Delivery to the Respiratory Tract Practical Considerations for Drug Delivery to the Respiratory Tract; John S. Patton Drug and Gene Delivery in the Lungs; Satoshi Uchida, Keiji Itaka, and Kazunori Kataoka Bio-Nanocapsules: Novel Drug Delivery; Shun’ichi Kuroda Section VI: Special Issues Physicochemical, Colloidal, and Transport Properties; Heinrich Hofmann, Lionel Maurizi, Marie-Gabrielle Beuzelin, Usawadee Sakulkhu, and Vianney Bernau Dosimetry for In Vitro Nanotoxicology: Too Complicated to Consider, Too Important to Ignore; Joel M. Cohen and Philip Demokritou Potential for Nose-to-Brain Delivery of Drugs; Lisbeth Illum The Developing Lungs; Akira Tsuda and Frank S. Henry Nanotoxicology; Dominique Balharry, Eva Gubbins, Helinor Johnston, Ali Kermanizadeh, and Vicki Stone Summary; Peter Gehr and Akira Tsuda Index

Akira Tsuda is a principal research scientist in the Molecular and Integrative Physiological Sciences Program at the Harvard School of Public Health. He is the author of more than 100 peer-reviewed articles and mentor of postdoctors (Harvard School of Public Health and Harvard Medical School). He serves as a reviewer for many international scientific journals, as well as research grants. He was a member of the NIH Respiratory Physiology, Respiratory Integrative Biology, and Translational Research Study Section, and is currently on the editorial board of the Journal of Applied Physiology and Journal of Aerosol Medicine and Pulmonary Drug Delivery. Peter Gehr is a professor emeritus at the University of Bern. Previously, he was chair of the Institute of Anatomy. He has served as visiting assistant professor at the Harvard School of Public Health and guest professor at the University of Nairobi. He spent sabbaticals at the University of Western Australia, National Jewish Health in Denver, and Harvard School of Public Health. He is currently the president of the Steering Committee of the National Research Program on Opportunities and Risks of Nanomaterials of the Swiss National Science Foundation, and a member of the Swiss Federal Commission for Air Hygiene.