Mitochondrial Function in Lung Health and Disease

Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

Chapter 1

 

Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases

 

Harijith Anantha, Prasad Kanteti, Panfeng Fu, Sainath R. Kotha, Narasimham L. Parinandi, and Viswanathan Natarajan

Chapter 2Regulation of Mitochondrial Functions by Transcription Factor NRF2

 

Narsa Machireddy, Wajiha Qureshi, Haranath Potteti, Dhananjaya V. Kalvakolanu, and Sekhar P. Reddy

 

Chapter 3

 

Mitochondrion: A Missing Link in Asthma Pathogenesis

 

Ulaganathan Mabalirajan, Anurag Agrawal, and Balaram Ghosh

 

Chapter 4

 

ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea

 

Ganesh K. Kumar, Gayatri Raghuraman, and Nanduri R. Prabhakar

 

Chapter 5

 

Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle

 

Niccole Schaible, Philippe Delmotte, and  Gary C. Sieck

 

Chapter 6

 

Mitochondrial Lipid Peroxidation in Lung Damage and Disease

 

Sainath R. Kotha, Travis O. Gurney, Miles U. Magalang, Thomas J. Hund, Abhay R. Satoskar, Peter J. Mohler, Krishna Rao Maddipati, Viswanathan Natarajan, and Narasimham L. Parinandi

 

 

 

Chapter 7

 

The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung

 

Lidza Kalifa and Michael A. O'Reilly

 

Chapter 8

 

Mitochondrial Function in Lung Health and Disease

 

Luis Puente-Maestu and Jorge Chancafe-Morgan

Chapter 9Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial DamageKatherine L. Tuggle and Michelle V. Fanucchi