MicroRNA in Regenerative Medicine

Regulating virtually all biological processes, the genome's 2,654 newly discovered variants of mature microRNAs - short ribonucleic acid molecules found in eukaryotic cells - hold a key role in the body's toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies.

In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering.

Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.

Part 1: Stem Cells 1. MicroRNA Biogenesis in Regenerative Medicine 2. Control of Pluripotency and Reprogramming 3. Epigenetic Modification of MicroRNAs 4. miRNAs in Bone Marrow-Derived Mesenchymal Stem Cells 5. miRNAs in Cancer Stem Cells 6. MicroRNAs in Neural Stem Cells 7. MicroRNAs in Embryonic Stem Cells 8. MicroRNAs in Normal and Malignant Myelopoiesis 9. MicroRNAs: Molecular Rheostats Regulating Stem Cells Self-renewal and Therapeutic Implications 10. MicroRNAs in Endothelial Progenitor Cells

Part 2: Development 11. MicroRNA Function in Muscle Homeostasis and Regenerative Medicine 12. MicroRNAs in Skin Fibrosis 13. MicroRNAs in Hematopoietic Stem Cell Biology 14. miRNAs in Bone Formation and Homeostasis 15. Lung Development 16. MicroRNAs in Pancreas and Islet Development 17. MicroRNAs in Skeletal Muscle Differentiation 18. MicroRNAs in Brain Development 19. MicroRNAs in the Retina and in Visual Connectivity 20. MicroRNAs in Neural Crest Development 21. Adipogenesis and Obesity

Part 3: Repair 22. MicroRNAs with Mega Functions in Cardiac Remodeling and Repair: The Micromanagement of Matters of the Heart 23. MicroRNAs in Vascular Remodeling and Repair 24. Skin Wound Healing 25. miRNAs in Bone Repair 26. MicroRNAs as Future Therapeutic Targets for Spinal Cord Injury 27. MicroRNA Regulation of Angiogenesis 28. Micromanaging Inflammation and Tissue Repair 29. MicroRNA Regulation of mTOR Function 30. OxymiRs in Regenerative Medicine 31. MicroRNAs and Exosomes in Cancer Diagnosis and Therapy 32. Organ Transplantation and MicroRNA Expression

Part 4: Regeneration 33. MicroRNAs in the Control of Neurogenesis in the Developing Cerebral Cortex 34. miRNAs in Transitions: EMT, MET, and EndoMT 35. MicroRNAs in Cardiac Regeneration 36. MicroRNAs in Liver Regeneration

Part 5: Methodology 37. MicroRNA Technology and Small-Molecule Delivery

Part 6: Intervention 38. Drug-MicroRNA Cross-Talk 39. Delivery and Biological Activity of Therapeutic miRNAs and miRNA Modifiers 40. RNA-Based Therapies for Bone Diseases 41. MicroRNA-Mediated Regulation of Cardiovascular Differentiation and Therapeutic Implications 42. Circulating MicroRNAs as Biomarkers

Part 7: Tissue Engineering 43. Nuclear Architecture and Transcriptional Regulation of MicroRNAs 44. MicroRNAs in Tissue Engineering and Regenerative Medicine 45. microRNAs in Renal Development and Regeneration 46. Mitochondrial MicroRNA in Tissue Regeneration 47. MicroRNA and Microbiota 48. Mitochondrial MicroRNA in Tissue Regeneration 49. MicroRNA Detection 50. Bone Formation and Homeostasis 51. Bone Formation and Homeostasis 52. MicroRNAs in Liver Disease 53. MicroRNA Bioinformatics 54. MicroRNAs in Ischemic Stroke 55. MicroRNAs in Senescence 56. Ocular miRNA

Dr. Chandan K Sen is a tenured Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. He is also the Associate Dean for Research at The Ohio State University Wexner Medical Center. After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Kuopio in Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory in California. In fall of 2000, Dr. Sen moved to The Ohio State University where established a program on tissue injury and repair. Currently, Dr. Sen is a Professor and Vice Chair of Research of Surgery. Dr. Sen serves on the editorial board of numerous scientific journals. He is the Editor in Chief of Antioxidants & Redox Signaling(www.liebertpub.com/ars) with a current impact factor of 8.456. He is the Section Editor of microRNA of Physiological Genomics, a journal of the American Physiological Society. Dr. Sen and his team have published over 250 scientific publications. He has a H-index of 64 and is currently cited 2000 times every year.