Microbial Cyclic Di-Nucleotide Signaling - Chou Shan-Ho (Curatore); Guiliani Nicolas (Curatore); Lee Vincent T. (Curatore); Römling Ute (Curatore) | Libro Springer 03/2021 - HOEPLI.it

home libri books ebook dvd e film top ten sconti 0 Carrello

Torna Indietro

chou shan-ho (curatore); guiliani nicolas (curatore); lee vincent t. (curatore); römling ute (curatore) - microbial cyclic di-nucleotide signaling

Microbial Cyclic Di-Nucleotide Signaling

; ; ;

Disponibilità: Normalmente disponibile in 15 giorni

140,98 €
133,93 €

Questo prodotto usufruisce delle SPEDIZIONI GRATIS
selezionando l'opzione Corriere Veloce in fase di ordine.

Pagabile anche con 18App Bonus Cultura e Carta del Docente

Facebook Twitter Aggiungi commento

Spese Gratis


Lingua: Inglese


Pubblicazione: 03/2021
Edizione: 1st ed. 2020


This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosisVibrio choleraeSalmonella typhimuriumEscherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described.

In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior.

Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.


                                                Microbial Cyclic Di-Nucleotide Signaling

Editors: Shan-Ho Chou, Nicolas Guiliani, Vincent T. Lee, Ute Römling






Table Of Contents

Part I     Biochemistry/Structural Biology - Enzymes

Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria (AnushyaPetchiappan, AvisekMahapa and Dipankar Chatterji) Chapter 2: Structure and regulation of EAL domain proteins (Dom Bellini, Andrew Hutchin, Odel Soren, Jeremy S. Webb, Ivo Tews & Martin A. Walsh) Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins (Julien Lescar) Chapter 4: Structure and function of HD-GYP phosphodiesterases (Serena Rinaldo, Alessandro Paiardini, AlessioPaone, Francesca Cutruzzolà, Giorgio Giardina) Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases (Lichuan Gu and Qing He)

Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides (Mona W. Orr and Vincent T. Lee)

Part II    Biochemistry/Structural Biology - Receptors Chapter 7: Detection of cyclic dinucleotide binding proteins (Vincent T. Lee)

Chapter 8: Non-canonical c-di-GMP binding modes (Shan-Ho Chou & Michael Y. Galperin)


Part III Biochemistry/Structural Biology - Sensing

Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction (Hannah Dayton, Marina K. Smiley, Farhad Forouhar, Joe J. Harrison, Alexa Price-Whelan, Lars E.P. Dietrich)

Part IV            Cyclic di-AMP biochemistry and physiology         

Chapter 10: Metabolic regulation by cyclic di-AMP signaling (Liang Tong, Joshua J. Woodward)

Chapter 11: Osmoregulation via cyclic-di-AMP signaling (Mark S. Turner,Thu Ngoc Minh Vu, Esteban Marcellin,Zhao-Xun Liang and Huong Thi Pham)

Part V Population diversity

Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity (Samuel Miller)

Part VI  Cyclic di-GMP and exopolysaccharide regulation

Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP (Jochen Zimmer)

Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling (M. Fata Moradali and Bernd H.A. Rehm)

Part VII Environmental bacteria

Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis (Cordelia A. Weiss and Wade C. Winkler)

Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group (Wen Yin, Lu Liu, Siyang Xu, Jin He)

Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation (Sarah M. Yannarell, Loni Townsley, Elizabeth A. Shank)

Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus (MaríaPérez-Burgos & Lotte Søgaard-Andersen)

Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria (Gen Enomoto, Annegret Wilde, and Masahiko Ikeuchi)

Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter (Guoliang Qian, Gaoge Xu, Shan-Ho Chou, Mark Gomelsky, and Fengquan Liu)

Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria (Castro Matías , Díaz Mauricio, Moya-Beltrán Ana and Guiliani Nicolas)

Part VIII                Pathogens

Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholerae (Erin Young, Garett Bonds, and Ece Karatan)

Chapter 23: Cyclic di-GMP regulation of gene expression (Meng-Lun Hsieh, Deborah M. Hinton, and Christopher M. Waters)

Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium (Ute Römling)

Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. campestris (Ya-Wen He, Wei Qian, Shan-Ho Chou)

Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis (Yinlan Bai and Guangchun Bai)

Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumoniae (Tiffany M. Zarrella and Guangchun Bai)

Part IX Gram-negative bacteria

Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa (Matthew J. Pestrak and Daniel J. Wozniak)

Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli (Nikola Zlatkov and Bernt Eric Uhlin)

Chapter 30: Cyclic di-GMP in Burkholderia spp (Grace I. Borlee, Mihnea R. Mangalea, and Bradley R. Borlee)

Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion (Karin Sauer)

Part X    Cyclic di-GMP signaling in eukaryotes

Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium (Zhi-hui Chen, Christina Schilde and Pauline Schaap)

Part XI Interference Strategies

Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules (Herman O. Sintim and Clement Opoku-Temeng)

Part XII            Novel cyclic di-nucleotides

Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes (Todd A. Wright, Andrew B. Dippel, Ming C. Hammond)

Chapter 35: Microbial cyclic GMP-AMP signaling pathways (Miriam S. Ramliden,Geoffrey B. Severin, Brendan J. O’Hara, Christopher M. Watersd, Wai-Leung Ng)

Part XIII           Honorary cyclic nucleotides

Chapter 36: 2’,3’-cyclic mononucleotide metabolism and possible roles in bacterial physiology (Benjamin M. Fontaine, Yashasvika Duggal, and Emily E. Weinert)

Part XIV          Horizontal gene transfer

Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives (Jonas Stenløkke Madsen)

Part XV                 Conclusion

Chapter 38: Conclusion (Shan-Ho Chou, Nicolas Guiliani, Vincent T. Lee, Ute Römling, LotteSøgaard-Andersen)



Shan-Ho Chou is currently a chair professor of the Institute of Biochemistry, National Chung Hsing University, Taiwan. He received his bachelor’s degree in chemistry from the National Taiwan Normal University, a master’s degree in biochemistry from the National Taiwan University, and a Ph.D. in chemistry from the University of Washington in Seattle, WA. He has been interested in studying protein and unusual nucleic acid complex structures and found several stable nucleic acid structures different from the WC base-paired duplex, which were published in several review papers in the Journal of Molecular Biology, Nucleic Acids Research and Trends in Biochemistry. He is now combining X-ray, nuclear magnetic resonance, and cryo-electron microscopy techniques to study the structures and functions of multi-domain proteins complexed with cyclic di-GMP and cyclic di-AMP.

Nicolas Giuliani received his PhD from the Université Aix-Marseille, France. He is actually full professor of Microbiology and Biotechnology at the Facultad de Ciencias, Universidad de Chile in Santiago, Chile.  His research is focused on the deciphering of molecular events involved in biofilm formation by acidophilic bacteria currently used in biomining processes. Initially focused on the characterization of quorum sensing systems, his research activities are now dealing with cyclic di-nucleotide second messenger signalling and the regulation of exopolysaccharides in Acidithiobacillus species. Nicolas Guiliani was President of the Chilean Society of Microbiology (SOMICH, 2013-2016) and President of the Association of Latinamerican Societies for Microbiology (ALAM, 2016-2018).

Vincent T. Lee is professor of Cell Biology and Molecular Genetics at the University of Maryland at College Park, USA. His long-standing research interests include bacterial pathogenesis, biofilm formation and regulation of microbial physiology by signaling nucleotides. One major focus in his research on signaling nucleotides is the identification of receptors that mediate the down-stream regulation by these signals. 

Ute Römling is professor of Microbial Physiology at the Karolinska Institutet in Stockholm, Sweden. Her long-standing research interest is the molecular and epidemiological analysis of biofilm formation in microorganisms with a focus on regulation by cyclic di-nucleotide second messenger signaling, implication of extracellular matrix production and biofilm-host interactions. Another major long-standing research interest concerns the survival and persistence mechanisms of a world-wide predominant clone of Pseudomonas aeruginosa found in patients and aquatic habitats. Ute Römling is a member of the European Academy of Microbiology, AcademiaNet and an adjunct faculty member at the University of Karachi, Pakistan.

Altre Informazioni



Condizione: Nuovo
Dimensioni: 235 x 155 mm Ø 1021 gr
Formato: Brossura
Illustration Notes:12 Illustrations, black and white
Pagine Arabe: 657
Pagine Romane: xviii

Utilizziamo i cookie di profilazione, anche di terze parti, per migliorare la navigazione, per fornire servizi e proporti pubblicità in linea con le tue preferenze. Se vuoi saperne di più o negare il consenso a tutti o ad alcuni cookie clicca qui. Chiudendo questo banner o proseguendo nella navigazione acconsenti all’uso dei cookie.