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Metabolomics Tools for Natural Product Discovery Methods and Protocols

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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Humana

Pubblicazione: 08/2013
Edizione: 2013





Trama

Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products.  Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.





Sommario

1. Bryophytes: Liverworts, Mosses and Hornworts – Extraction and Isolation Procedures

                Yoshinori Asakawa and Agnieszka Ludwiczuk

 

2. Plant Tissue Extraction for Metabolomics

                Ute Roessner and Daniel Anthony Dias

 

3. Detection of Polar Metabolites through the use of Gas Chromatography – Mass Spectrometry

                David P. De Souza

 

4. A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems

                Nirupama Samanmalie Jayasinghe and Daniel Anthony Dias

 

5. A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation

                Damien L. Callahan and Candace E. Elliot

 

6. Lipidomics –Extraction Protocols for Biological Matrices

                Thusitha Wasntha Thilanka Rupasinghe

 

7. Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy

                John Robert Sheedy

 

8. NMR Spectroscopy: Structure Elucidation of Cycloelatenene A: A Natural Product Case Study

                Sylvia Urban and Daniel Anthony Dias

9. NMR-Based Metabolomics: A Probe to Utilize Biodiversity

                Lúcia P. Santos Pimenta, Hye Kyong Kim, Robert Verpoorte, and Young Hae Choi             

 

10. Extraction Protocol for Non-Targeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and their Algal Symbionts

                Benjamin R. Gordon, William Leggat, and Cherie Motti

 

11. Determination of Absolute Configuration Using Single Crystal X-ray Diffraction

                Abigail L. Albright and Jonathan M. White

 

12. Natural Product Chemistry in Action:  The Synthesis of Melatonin Metabolites K1 and K2

                Helmut M. Hügel and Oliver A.H. Jones

 

13. Discovery, Biosynthesis, and Rational Engineering of Novel Enterocin and Wailupemycin Polyketide Analogues

                John A. Kalaitziz

 

14. Bioassays for Anticancer Activities

                Janice McCauley, Ana Zivanovic, and D. Skropeta

 

15. Screening for Anti-Diabetic Activities

                Rima Caccetta and Hani Al Salami

 

16. Screening for Antibacterial, Antifungal and Anti-Quorum Sensing Activity

                Elisa J. Hayhoe and Enzo A. Palombo

 

17. Metabolomics and Dereplication Strategies in Natural Products

                Ahmed Fares Tawfike, Christina Viegelmann, and RuAngelie Edrada-Ebel

 

18. Bridging the Gap: Basic Metabolomics Methods for Natural Product Chemistry

                Oliver A.H. Jones and Helmut M. Hügel

 

19. Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for de novo Structure Identification by Micro-NMR

                Philippe J. Eugster, Gaëtan Glauser, and Jean-Luc Wolfender

 

20. Statistical Analysis of Metabolomics Data

                Alysha M. De Livera, Moshe Olshansky, and Terence P. Speed











Altre Informazioni

ISBN:

9781627035767

Condizione: Nuovo
Collana: Methods in Molecular Biology
Dimensioni: 254 x 178 mm Ø 7538 gr
Formato: Copertina rigida
Illustration Notes:X, 311 p. 83 illus., 33 illus. in color.
Pagine Arabe: 311
Pagine Romane: x


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