Mechanics of Biomaterials Fundamental Principles for Implant Design

Teaching mechanical and structural biomaterials concepts for successful medical implant design, this self-contained text provides a complete grounding for students and newcomers to the field. Split into three sections: Materials, Mechanics and Case Studies, it begins with a review of sterilization, biocompatibility and foreign body response before presenting the fundamental structures of synthetic biomaterials and natural tissues. Mechanical behavior of materials is then discussed in depth, covering elastic deformation, viscoelasticity and time-dependent behavior, multiaxial loading and complex stress states, yielding and failure theories, and fracture mechanics. The final section on clinical aspects of medical devices provides crucial information on FDA regulatory issues and presents case studies in four key clinical areas: orthopedics, cardiovascular devices, dentistry and soft tissue implants. Each chapter ends with a list of topical questions, making this an ideal course textbook for senior undergraduate and graduate students, and also a self-study tool for engineers, scientists and clinicians.

Part I. Materials: 1. Biocompatibility, sterilization and materials selection for implant design; 2. Metals for medical implants; 3. Ceramics; 4. Polymers; 5. Mechanical behavior of structural tissues; Part II. Mechanics: 6. Elasticity; 7. Viscoelasticity; 8. Failure theories; 9. Fracture mechanics; 10. Fatigue; 11. Friction, lubrication and wear; Part III. Case Studies: 12. Regulatory affairs and testing; 13. Orthopedics; 14. Cardiovascular devices; 15. Oral and maxillofacial devices; 16. Soft tissue replacements; Appendix A. Selected topics from mechanics of materials; Appendix B. Table of material properties of engineering biomaterials and tissues; Appendix C. Teaching methodologies in biomaterials; Glossary; List of symbols.

Teaching mechanical and structural biomaterial concepts for successful implant design, this self-contained text is suitable for engineers, scientists and clinicians. Medical device case studies (including orthopedics, cardiovascular medicine, dentistry and soft tissues), step-by-step design guidelines and problem sets throughout, make this book ideal for course use and for self study.

Lisa A. Pruitt is the Lawrence Talbot Chair of Engineering at the University of California, Berkeley and also serves as an adjunct professor in the Department of Orthopedic Surgery at the University of California, San Francisco. She recently served as the Associate Dean of Lifelong Learning and Outreach Education in the College of Engineering and has received numerous awards including the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring (2004) and the Graduate Student Instructor Mentor Award from the University of California, Berkeley (2009).
Ayyana M. Chakravartula received her Ph.D. in Mechanical Engineering from the University of California, Berkeley in 2005. She currently works at Exponent, Inc. in Menlo Park, CA, in its Mechanics and Materials practice. She has worked as a research scientist at the Cambridge Polymer Group in Boston, MA, and has served as an adjunct lecturer at Boston University. She has mentored numerous students, interns and research assistants in her graduate and postgraduate career.

Teaching mechanical and structural biomaterials concepts for successful medical implant design, this self-contained text provides a complete grounding for students and newcomers to the field. Split into three sections: Materials, Mechanics and Case Studies, it begins with a review of sterilization, biocompatibility and foreign body response before presenting the fundamental structures of synthetic biomaterials and natural tissues. Mechanical behavior of materials is then discussed in depth, covering elastic deformation, viscoelasticity and time-dependent behavior, multiaxial loading and complex stress states, yielding and failure theories, and fracture mechanics. The final section on clinical aspects of medical devices provides crucial information on FDA regulatory issues and presents case studies in four key clinical areas: orthopedics, cardiovascular devices, dentistry and soft tissue implants. Each chapter ends with a list of topical questions, making this an ideal course textbook for senior undergraduate and graduate students, and also a self-study tool for engineers, scientists and clinicians.